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So I think the association is: measure the peak VO2 after a single exercise test, and measure NEGR1 in the plasma immediately after the exercise. In people with ME/CFS, the higher the VO2, the higher the NEGR1. And in controls, the correlation was not significant. I'm hesitant to put too much...

See this post discussing a talk from the 2025 Portugal conference about this study:

Authors responded: They didn't say anything about the commenter's main point - that the pre-selected minimum important difference was not achieved.

Putting the PASC Score to the Test: Clinical vs. Statistical Accuracy in Long COVID Diagnosis Objective To validate the RECOVER Post-Acute Sequelae of SARS-CoV-2 infection (PASC) score in a cohort of patients who develop long COVID (LC) or fully recover while iteratively improving the tool’s...

Part 2 from Health Rising: Low Brain Norepinephrine Levels in ME/CFS and Long COVID Pt. II: A ChatGPT Based Treatment Program Yet, the blog goes on to describe a treatment protocol developed by ChatGPT for these unvalidated findings. Some of the other interventions recommended by ChatGPT: I...

I think there's some confusion due to a mistake in the AI summary. He's describing dextro-naltrexone, not dextrorphan (and also not dextro-naloxone). Dextro-naltrexone is the mirror molecule of the commonly used low dose naltrexone.

Discussion relating to an article by Martin Rücker about Germany's post-infectious disease initiative have been moved to the dedicated thread: Germany's "National Decade Against Post-Infectious Diseases"

What do you mean by them claiming they are equal? Aren't they claiming they are not equal based on their results?

The Coronavirus Disease 2019 Pandemic is Associated with a Substantial Rise in Frequency and Severity of Presentation of Youth-Onset Type 2 Diabetes Published: 2022 [Line breaks added] Objectives: To evaluate the frequency and severity of new cases of youth-onset...

Wow, I'm surprised how critical this is. I mean, we're talking about €3 million, so it's good to make sure the trial design is sound. But is it typical to take issue with so many parts of a protocol? I put the image into OCR to turn into text for easier reading, and added line breaks:

The Central Role of Macrophages in Long COVID Pathophysiology McMillan, Philip; Turner, Anthony; Uhal, Bruce [Line breaks added] Abstract This review article attempts to provide a unifying hypothesis to explain the myriad of symptoms and predispositions underlying the development of PASC...

It's a very strange system we currently have. The authors doing the science have to pay to publish. And the people reading the science have to pay. The peer-reviewers don't get paid for their help making money for the publisher. I don't know what value a publisher adds that can't be provided by...

Absolutely. Authors often reply, and sometimes get into spirited debates.

I think Pubpeer is kind of an in-between. It's considered fairly reputable because a large amount of comments about image manipulation and other issues have been posted about on there and led to retractions. But it's not officially attached to any journal, just a non-profit. While it might be...

The thing is, unless governments make laws saying you can't criticize a study on the internet unless you have uploaded an ID, which sounds ridiculous to me, it can't practically be achieved. If S4ME and Pubpeer take the initiative and somehow require your real name, then people will just start...

While I'm all for free speech and being able to freely point out issues with papers, I just want to at least acknowledge that PubPeer can at least theoretically be weaponized against authors. Moderators on PubPeer don't thoroughly check every comment for accuracy. So if someone had a grudge or...

With too low, I was thinking it could be the body not keeping up with normal axon repair/replacement/plasticity processes that maybe are supposed to happen after exertion.

I've only quickly skimmed, but the axon guidance gene set being most significant stood out. This was based on proteins measured before exercise on day 2. The negative enrichment score indicates that proteins in the pathway were downregulated. Figure 4: These are the leading edge genes in the...

I only read the abstract, but thought it might be kind of interesting since I would say S4ME's discussions often seem to fit the "post-publication peer review" idea.

An expert criticism on post-publication peer review platforms: the case of pubpeer Abstract While traditional peer review offers advantages in academic publishing, it is often hampered by significant weaknesses, leading to frustration among many authors. Scientific discoveries after...