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Pulling out some quotes about the difference from a quick scan:

I'm just concerned that there's no other way to read the sentence when it uses "and" than that it's suggesting they are all involved: Maybe "or" instead?

Thanks for the blog! I think fine mapping refers to identifying the causal variant out of all the significant variants, not identifying the gene that the variant affects. I think that would be 'gene prioritization': - https://royalsocietypublishing.org/doi/10.1098/rsob.190221 --- I don't...

Post-acute non-specific symptoms following COVID-19 vaccination: a Danish population-based study Christina Bisgaard Jensen, Kristoffer Torp Hansen, Bodil Hammer Bech, Stefan Nygaard Hansen, Henrik Nielsen, Charlotte Ulrikka Rask, Per Fink, Thomas Meinertz Dantoft, Torben Jørgensen, Jeremy A...

Targeting Symptoms of Fibromyalgia Through Transcutaneous Electrical Nerve Stimulation (TENS): A Systematic Review of Current Systematic Reviews Masoud Sahebari, MD, Fateme Tahmasbi, MD, Alireza Rahimi-Mamaghani, MD, MSc, FIPP [Line breaks added] Background Fibromyalgia syndrome (FMS) is a...

Inflammatory predictors of Post-COVID fatigue A. Nuber-Champier, G. Breville, P. Voruz, I. Jacot de Alcântara, P.H. Lalive, G. Allali, L. Benzakour, K.-O. Lövblad, O. Braillard, M. Nehme, M. Coen, J. Serratrice, J.-L. Reny, J. Pugin, I. Guessous, B.N. Landis, A. Cionca, F. Assal, J.A. Péron...

Yes. Unfortunately, I don't have a lot of examples off the top of my head. But for example, they don't really know how SSRIs work for depression (if they actually work at all and it's not placebo). Wikipedia Another example is general anesthesia:

You could just see that it works when patients take it for an unrelated reason. That appears to be the basis of all the B cell depletion drug trials in Norway. Cancer patients took chemo drugs and their ME/CFS got better. Wikipedia says the tree that contains a similar chemical to Aspirin was...

T Cell Dysregulation in Long-COVID: Immune Profiling and the Potential Role of Short-chain Fatty Acids in Modulating T-cell Functionality Zhihua Wu, Kieran Tuohy, Frederique Ponchel Abstract Long-COVID (LC) affects over 400 million individuals globally and is characterised by persistent...

@elimrogers Thank you for joining and offering to share your paper. Unfortunately, it's really hard for me to follow these types of historical/sociological topics, so I'm not sure how much I can personally understand or contribute. I'm sorry that comments on this forum have been hurtful. But...

Can you clarify what is offensive? She can't write about ME/CFS because she doesn't have it? I can't follow what your criticism of the piece is.

There are some resources for learning about the immune system here: https://www.s4me.info/threads/learning-about-the-immune-system.43381/ And Sasha talks about that book here: https://www.s4me.info/threads/visual-media-for-learning-biology-medicine.39380/post-611356

Quoting a post about another immune system resource, the book 'Immune' from Kurzgesagt, from the thread, Visual media for learning biology/medicine:

Over £1000 in a day. Very nice work @Joan Crawford.

I always thought of it as some side effect or other circumstance occurring that makes participants more certain what group they're in, unrelated to the outcome of interest. For example, if a patient gets a characteristic rash that is only known to happen with the active drug, they're no longer...

Muscle and cerebral oxygenation during exercise in fibromyalgia: a near-infrared spectroscopy study Taneli Lehto, Teemu Zetterman, Dominique Gagnon, Ritva Markkula, Jari Arokoski, Eija Kalso & Juha E. Peltonen [Line breaks added] Purpose We studied muscle and brain oxygenation during...

No, not that I can see.

Now published: Web | PDF Only minor formatting changes to abstract from above version.

Previous paper: Development and evaluation of blood-based prognostic biomarkers for COVID disease outcomes using EpiSwitch 3-dimensional genomic regulatory immuno-genetic profiling, 2024, Hunter et al Thread for press release about that paper: Oxford BioDynamics shares gain on Covid test...

If I understood it correctly, this study looked at absolute count of CD16+CD56+ cells at baseline in the blood, like the ME/CFS study, and found no correlation with response to daratumumab: Effects of daratumumab on natural killer cells and impact on clinical outcomes in relapsed or refractory...