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I'm really interested in what is going on behind the scenes with IGHV3-30. Is anything happening? Three studies with a positive result on something so specific feels to me like an "all hands on deck" moment. And there's a way this finding potentially relates to daratumumab. If dara works, it...

It's at least very similar, if not the same thing: Caregiver-Fabricated Illness in a Child: A Manifestation of Child Maltreatment, 2013, Pediatrics

Reassessing Chronic Lyme Disease and Post-Treatment Lyme Disease Syndrome as Focal Infections András Lakos, Gyöngyi Nagy, Zoltán Varga, Péter Rásonyi-Kovács, Sándor Hornok [Line breaks added] Abstract The complete clinical spectrum of Lyme borreliosis has been recognized for nearly 50 years...

Deployment-Related Toxic Exposures, Mental Health Problems, and Suicide Outcomes among Gulf War Era U.S. Veterans Tapan A. Patel, Kyle J. Bourassa, Patrick S. Calhoun, Jean C. Beckham, Mary J. Pugh, Nathan A. Kimbrel [Line breaks added] Abstract Exposure to toxins, such as pesticides, smoke...

We've deleted posts about some tweeted data. We generally don't allow discussion of personal health data from identified people without their permission.

From some cursory research I did previously, it seemed like military got a relatively low dosage:

Feasibility and tolerability of dual-target repetitive transcranial magnetic stimulation (rTMS) for treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): An open label pilot study Juliana Corlier, Hrag Peltekian, Thomas E. Valles, Cole D. Matthews, Doan Ngo, Reza...

Part of the discussion was about how the difference might have been driven by contraceptive use: I think it would have made sense to consider contraceptive use in this paper as well, but I don't see that word mentioned.

Linking to the thread for a fibromyalgia GWAS since there was a signal in the same region and they believe it may be related to GPR52: The two relevant loci in DecodeME, showing that there may be a signal in the HTT region in ME/CFS as well (black triangles are locations of top hits from...

More from the paper: As the images I posted above show, there seem to be at least suggestive signals (p<5e-6) at these same two locations in DecodeME. So maybe GPR52 and HTT form an important pathway in ME/CFS as well. Another drug target:

They did match by age, so there should be the same proportion of elderly people in the control group.

The gut microbial composition is different in chronic fatigue syndrome than in healthy controls Monika Prylińska-Jaśkowiak, Hanna Tabisz, Sławomir Kujawski, Beata R. Godlewska, Joanna Słomko, Beata Januszko-Giergielewicz, Modra Murovska, Karl J. Morten, Łukasz Sokołowski & Paweł Zalewski [Line...

Fibromyalgia and hand diseases: A case-control study Eli Magen, Suhail Aamar, Viktor Feldman, Israel Magen, Eugene Merzona, Ariel Israel [Line breaks added[ Highlights • FM triples risk of carpal tunnel, De Quervain’s, and trigger finger. • FM linked to higher rates of carpal tunnel release...

Endometriosis and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis Sabrina Compton, Rodolf Alkabalan, Judd Cadet, Azin Mastali, Prakash V. A. K. Ramdass Background/Objectives Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and endometriosis...

Unpublished trial of CoQ10 in GWI where it doesn't appear to help:

Now published: Gulf War Illness, Fibromyalgia, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID Overlap in Common Symptoms and Underlying Biological Mechanisms: Implications for Future Therapeutic Strategies David Mantle, Joan Carles Domingo, Beatrice Alexandra Golomb, Jesús...

Now published, see post #6 ------------------------------------ Relationships Between Fatigue, Cognitive Function, and Upright Activity in a Randomized Trial of Oxaloacetate for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Suzanne D Vernon, Candace Rond, Yifei Sun, Shad Roundy, Jennifer...

Anti-neuronal and anti-mitochondrial autoantibodies are associated with lower functional status and more severe respiratory symptoms in post COVID syndrome Antje Vogelgesang, Anke Steinmetz, Angela Stufano, Valentina Schino, Domenico Plantone, Agnes Flöel, Guglielmo Lucchese [Line breaks...

Cases are the ones with fibromyalgia. Controls are healthy. And I meant participants as everyone combined.

Maybe you meant total participants, but in terms of cases it's around 54,000. Around 3 times more.