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I pulled up the top hits from this study and compared to DecodeME to look for those that are in the same general location as at least a somewhat significant locus in ME/CFS. So these images are the results for ME/CFS, but with the top fibromyalgia SNPs marked as black triangles and with their...

I see some familiar genes from DecodeME: RABGAP1L, OLFM4, DCC

I don't know if it's circular. It's more like NK cells might be relevant because of the study correlation. And ADCC might be relevant if NK cells are relevant. True, there might be other possibilities for why NK cells were significant (including randomness).

If we suppose that high NK count is related to better antibody dependent cell cytotoxicity, might the fact that the correlation was with blood NK cells provide a clue about where the cells that need to be killed are? The multiple myeloma studies found correlations with NK cells in the bone...

Well nothing indicated that people with high NK cells had worse ME/CFS. There's the possibility that NK count doesn't have much to do with the illness itself, it's just if you happen to be a person with high numbers, dara can work more effectively. An imaginary related example is if there was...

I think generally LD is related to where DNA tends to be cut when DNA shuffling is happening during cell division. I'm not sure if there's any relation between regions that tend to stay together and the locations of specific genes, but maybe it happens. I don't know enough to say it's not...

Hmm, I'd be cautious about ascribing similarities in length between a gene and a signal as more than a coincidence. Here's that area except with LD colors in reference to the top SNP (purple diamond) of that little length of SNPs: It looks like that's just a stretch of SNPs that are in strong...

Discussion about the interpretation of high p values was moved to this thread: Understanding Statistics

I brought this up with the author of the blog post. He stood by his statements and I would tend to agree with him. I didn't ask for permission to quote his response, so I won't copy it. Part of his response though is that he thinks the statement from the ASA might be being misinterpreted or...

Now published: Burden of Disease in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Scoping Review [Line breaks added] Objective Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious chronic and complex multi-system disease characterised by symptoms such as...

Thanks, updated title. I assumed it was going to be DaraME to follow the theme of CycloME and RituxME.

Any chance you measured NK cell count around that time? Or ever?

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Good call, I think you're right. I found an R function that calculates Spearman p value with permutations (perm.cor.test). I ran it a few times with 100,000 permutations and the p value ranges from around .0115 to .0122, so right around what they reported. Using this method for the NK vs diff...

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The health and economic burden on family caregivers of persons with me/cfs diagnosis: a register data study from Norway Anne Kielland, Jing Liu & Kjartan Sarheim Anthun [Line breaks added] Background Myalgic encephalomyelitis is an illness that affects the labor capability and need for...

Maybe StudyME? Though this doesn't seem to be a strict database of people with ME/CFS. I think you just provide your location and select which kinds of studies you want to be notified about.

It's a good question. Ideally, we'd see if there's still a correlation even if all the people with depression were excluded in decodeme. (Or ME/CFS in this study).

Yeah, that's what I tried first. I also tried this in R and got the same result: Maybe it is some other calculation in SPSS.

I wanted to see how the baseline NK correlation compares when using steps instead of SF-36. They say that the correlation between baseline NK and change in SF-36 is r=0.77, p=0.012. Weirdly, I get the same r of 0.77, but I can't seem to get the same p, and instead get 0.0089. Close but a little...