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One test is testing if either group's correlation is different from zero. The other is testing if the groups' correlations are different from each other. The first not being significant doesn't mean there's definitely no correlation between these metabolites, just that with the data we have...

Do you mean that it doesn't appear to be statistically valid? Each group on its own might have a correlation that is too small to be statistically significant when you're testing if the correlation is different from zero correlation. But the distance between the correlation in ME/CFS and the...

Is it possible that a contraceptive changing one hormone level might lead to downregulation or upregulation of these core enzymes so that many more hormones are affected than just progesterone?

The point isn't that meds would break down those channels. It's that if half the people take a med that increases the output metabolite of a pathway and half don't, with the input metabolite not being directly affected, the correlation between the input and output becomes much harder to detect...

I'm having trouble imagining how a specific factor would eliminate 52 (virtually all) different correlations between different metabolites. The simplest explanation to me seems like increased variability preventing significance. And I can imagine there might be increased variability in hormones...

ME Research UK e-newsletter – July 2025

Interesting that males are more at risk than females of clinically diagnosed PACS here.

Sociodemographic factors, biomarkers and comorbidities associated with post-acute COVID-19 sequelae in UK Biobank Marta Alcalde-Herraiz, Shahed Iqbal, Jeffrey J. Wallin, Yunhao Liu, Wildaliz Nieves, Mark Berry, Marti Catala, Daniel Prieto-Alhambra & Junqing Xie [Line breaks added] Abstract...

Association of COVID vaccinations and treatments with long COVID beyond 6 months: a case-control study on the adult population in a large integrated healthcare system in the United States from 2020 to 2023 Curtis Liu, Celina Liu, Rui Yan, Davida Becker, Jia Xiao Shi, Jeffrey Slezak, Diane Jerng...

Effect of nonpharmacologic therapies on depressive symptoms in patients with chronic fatigue syndrome: a network meta-analysis Baiyi Jiang, Mengru Cao, Xue Xia, Long Wang Background Depression or depressive symptoms exacerbate the burden in patients with chronic fatigue syndrome (CFS). The...

Neuroimmune Modulation in Adults with Rheumatoid Arthritis and Inadequate Response or Intolerance to Biological or Targeted Synthetic DMARDs: Results at 12 and 24 Weeks from a Randomized, Sham-Controlled, Double-Blind Pivotal Study John Tesser, Joshua June, Pendleton Wickersham, Jane Box...

Gulf War Illness and Inflammation: Association of symptom severity with C-reactive protein Lisa M. James, Brian E. Engdahl, Rachel A. Johnson, Apostolos P. Georgopoulos [Line breaks added] Abstract Gulf War Illness (GWI) is a chronic multi-system condition that has affected one-third of U.S...

S4ME got a mention:

Science: "Genomewide study makes ‘quantum leap’ in understanding stuttering" 'In the new study, researchers turned to 23andMe, which assembled a vast database of users’ genetic information and other data. They analyzed the genetic profiles of 99,076 users who answered “yes” to the company’s...

Merged posts -------------------- ABC News: 'Justin Timberlake reveals Lyme disease diagnosis' 'Music superstar Justin Timberlake has been diagnosed with Lyme disease.' ----- '"If you've experienced this disease or know someone who has -- then you're aware: living with this can be...

This appears to be a followup to this previous study: Trial thread: Closed - Fred Friedberg (University of Stonybrook) Hydrogen Rich Water; Heart rate variability biofeedback in CFS Paper thread: Hydrogen water and heart rate variability biofeedback as treatments for chronic fatigue syndrome...

Email from Open Medicine Foundation: Heart rate variability as an autonomic marker of improvement in ME/CFS in a hydrogen water treatment study Volunteers needed. ME/CFS research of a potential treatment (Hydrogen Enriched Water) and treatment biomarker (heart rate variability). New 16-week...

Hydrogen Water Dosing Study for ME/CFS Sponsor Stony Brook University Information provided by Fred Friedberg, Stony Brook University Detailed description Previous clinical studies (8-12 week intervention trials) have indicated that H2 enriched water reduces concentrations of markers of...

Posting a newsletter @Peter T received: We want to share with you important behind-the-scenes work #MEAction is doing to help standardize how researchers measure post-exertional malaise (PEM) - the defining symptom of ME/CFS - in studies. Our Scientific Director, Jaime Seltzer, is a member...