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One of the genes that was significant in both cohorts, DCC, was also significant in depressive symptoms not associated with recent stress: S4ME Thread: Disentangling nature and nurture: Exploring the genetic background of depressive symptoms in the absence of recent stress exposure using a GWAS...

Disentangling nature and nurture: Exploring the genetic background of depressive symptoms in the absence of recent stress exposure using a GWAS approach Berta Erdelyi-Hamza, Dora Torok, Sandor Krause, Nora Eszlari, Gyorgy Bagdy, Gabriella Juhasz, Xenia Gonda Highlights • Heterogeneity of...

Neuroscience News: 'GLP-1 Drug Cuts Migraine Days in Half' "A diabetes medication that lowers brain fluid pressure has cut monthly migraine days by more than half, according to a new study presented today at the European Academy of Neurology (EAN) Congress 2025. Researchers at the Headache...

Effectiveness and tolerability of liraglutide as add-on treatment in patients with obesity and high-frequency or chronic migraine: A prospective pilot study Simone Braca, Cinzia Valeria Russo, Antonio Stornaiuolo, Gennaro Cretella, Angelo Miele, Caterina Giannini, Roberto De Simone [Line...

S4ME thread: Functional characterisation of CD8+ T cells mobilised with acute supramaximal high-intensity interval exercise: implications for immune surveillance, 2025, Strömberg et al

Functional characterisation of CD8+ T cells mobilised with acute supramaximal high-intensity interval exercise: implications for immune surveillance Anna Strömberg, Mirko Mandić, Brennan J Wadsworth, Sebastian Proschinger, Seher Alam, Lisa MJ Eriksson, Laura Barbieri, Eric Rullman, Helene...

Dysregulated monocyte compartment in PACS patients Romy Kronstein-Wiedemann, Madeleine Teichert, Elisa Michel, Janina Berg, George Robinson, Kristin Tausche, Martin Kolditz, Johannes Bergleiter, Jessica Thiel, Dirk Koschel, Stephan R. Künzel, Kristina Hlig, Torsten Tonn, Manuela Rossol...

Oops, fixed link, thanks.

I don't think "influencing" necessarily means increasing risk. They worded it differently in the paper:

Data sources 7363 is a lot of samples. I'm also curious where they're from. I'm not sure what IEU is. Maybe this: https://gwas.mrcieu.ac.uk/

Could you quote where they said these increase risk? They seem to consistently say cheese reduced risk of ME/CFS, except strangely in one spot they say: I don't see any data about total vs. fermented. The tables only refer to "cheese consumption".

Interesting that NK cells and CD38+ B cells popped up. Maybe some connection to daratumumab, which kills CD38 cells and apparently helped with ME/CFS symptoms, but only in those with high enough NK cell count.

This article has been retracted, see post #31. ---------------------------------------------------------- Causal Relationship Between Diet, Lipids, Immune Cells, and Chronic Fatigue Syndrome: A Two-Mediation Mendelian Randomization Study Jixu Li, Qi Qin, Yiran Zhu, Yulu Qian, Jialu Yin, Xin...

Really? She couldn't figure out whether or not Hilda was talking about the definition of ME/CFS changing? It might have made sense to look at the IOM report that Hilda cited, the subtitle of which is "Redefining an Illness". If the review is about "chronic fatigue" in general, she doesn't...

Again missed the point. She's saying the Cochraine review is out of date because newer studies have more evidence on harms, not that the review didn't adequately assess harms in the studies it looked at.

- https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003200.pub9/detailed-comment/en?messageId=457323262

They seem to have not understood her point. They are the ones that mentioned NICE in their paper, and she's pointing out that they mentioned the old one that agrees with their conclusions instead of the new one that does not.

Collecting all the threads we have about daratumumab: ME/CFS Patent: Method for the treatment of CFS using an inhibitory or cytotoxic agent against plasma cells, 2021, Fluge, Mella [Protocol] 2022 Pilot study in Norway - Daratumumab in ME/CFS [Protocol] Norway: Study of Daratumumab Injections...

Similarly: NK Cell Phenotype Is Associated With Response and Resistance to Daratumumab in Relapsed/Refractory Multiple Myeloma (2023, HemaSphere)

Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD Yuanxin Zhong, Larry W. Baum, Justin D. Tubbs, Rui Ye, Lu Hua Chen, Tian Wu, Se-Fong Hung, Chun-Pan Tang, Ting-Pong Ho, Robert Moyzis, James Swanson, Chi-Chiu Lee, Pak C. Sham & Patrick W. L...