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I don't know how accurate those two AI statements above are (1, 2), but they seem to me clear and concise, which is always a big plus, if for no other reason than that makes it much easier to spot the limitations and flaws. It demonstrates what I have long thought is the main potential benefit...

It is all marketing. His underlying belief about ME/CFS being a psycho-behavioural problem has not changed one bit, since his first comments on it in the formal literature back in the mid-1980s. Don't listen to what Wessely claims to believe, look at what he actually does, very consistently.

Wessely is just pulling his usual ex cathedra act. It is true because the Great Man said so. Accountability is coming, Sir Simon, and there is nothing you can do to stop it. And you thoroughly deserve it. You have been a deeply malign influence on this world, and have caused immense and...

I strongly suspect that the undiagnosed or misdiagnosed rate, especially among the milder end of the spectrum, is going to be an important confounder in general. Nor would I be surprised if a decent chunk of that 'misdiagnosis' in particular was from wiser and more compassionate clinicians...

And an unnecessary burden.

The only words I want to hear from that man, and his fellow travelers, are 'sorry', and 'I resign'. And at well above the average rate for the general population. The poorly understood illness, which is estimated to affect many millions of people worldwide, is associated with debilitating...

So is an infection triggered neuro-immune condition a broadly correct characterisation of ME/CFS, based on these findings? Maybe it is identifying currently healthy people who have an increased genetic risk of getting ME/CFS. Would be interesting to follow that group for a few decades and see...

Stronger associations would have been nice, and there is the issue of inconsistency across studies to be addressed. But otherwise a very welcome and important step forward, that should help focus research efforts on more productive possibilities. Thank you to all involved. :thumbup...

Thank you, @Simon M. Clear and informative as always. :thumbup: Any idea how expensive, and how much value there is in a full detailed gene map study? Or do we have enough now to start focusing down?

The whole energy/fatigue paradigm, and especially 'managing' it, has been a disaster. It has completely derailed understanding and treatment.

PCS is a high subjective financial burden What does 'subjective' mean in this context? Personal?

Yes. The correct interpretation is that doctors send patients to psychiatrists, not that patients 'see' psychiatrists. Don't know about other countries, but here a patient can't just go to a psychiatrist. They have to be referred to them by another doctor (usually a GP/PCP).

Functional motor disorder often causes persistent disabling symptoms that are associated with high healthcare costs. In recent years, specialist physiotherapy, informed by an understanding of functional motor disorder, has emerged as a promising treatment, but there is an absence of evidence of...

They all do. They have a basic template including stuff like how common it is, how difficult it is, how much it costs the economy, how important the sales pitch is, blah blah blah.

Gets released at 0430 Thursday my time, and it's late Tuesday afternoon here. So two more for me.

Now vastly more complicated and voluminous due to AI, and only likely to quickly get even worse.

who do not conduct any quality controls on submissions Maybe they are just following the example of the established mainstream journals (at least in some areas)?

Exactly. This is one of those studies that will tell us something useful, maybe even important, regardless of the actual results. Strong, weak, null. They are all meaningful outcomes that will help focus future research efforts. All that matters is that it is methodologically robust. Thanks...

Interesting. :nerd:

I don't think this necessarily holds.