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I have left a comment. I don't have the energy to spend a long time on this, but I think I covered some of the main criticisms here. -- The authors report an ME/CFS prevalence rate of 10.8% in their control group. This is 10–20 times larger than the best estimates of the prevalence rate from...

It really seems to be a big problem now, made much worse by poor long covid research.

Will be interesting to see if this gets published. I have no doubt given scientific publishing and peer review standards that they'll find a home for it.

I don't even know where you'd start with this crap. Probably a lost cause.

It's not significant if your error bars are longer than a giraffe's neck.

This must be the most bizzare abstract I've read for many, many years.

Interesting links between chronic stress, depression, and autophagy, bringing in mOTR and the anti-depressive effects of rapamycin.

Chronic stress remodels brain homeostasis, in which persistent change leads to depressive disorders. As a key modulator of brain homeostasis, it remains elusive whether and how brain autophagy is engaged in stress dynamics. Here we discover that acute stress activates, whereas chronic stress...

I'm afraid I'm skeptical of this story. Urine thyroid tests don't seem to be used at all, and are in fact recommended against, whereas blood thyroid tests are and have been for decades. Here's a paper in Dutch that concludes that 24-h urine tests for T3 and T4 are not accurate and cannot be used...

This paper suggests that bisoprolol has similar efficacy as propranolol for PoTS: https://www.neurotherapeuticsjournal.org/article/S1878-7479(23)01061-9/fulltext (I realise not all OI is PoTS.)

There's reasonably good evidence that propranolol improves symptoms of POTS, e.g., https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.846501, but I'm not sure its fully understood why. One theory is that excessive heart rates don't allow the heart to fill properly and so cardiac output...

What is the stats/maths behind this statement, please, i.e., where does the 150 come from?

Alan seems a touch angry, but I have to say, unless I am missing something, I am not really seeing the significance of this particular paper and its results, except for the fact some results have been replicated.

I think that's the whole point.

I have one reading, from a medical I had at the University of Leeds in 2014, before extended fieldwork. The value was 214 iu/L, which wasn't flagged because the stated normal range was given as 70–300 iu/L, but looking now this range seems wrong for an adult and my result is actually high.

There was a short section on Radio 4 this morning, at around 7.20am I think. Chris Ponting talking to Nick Robinson about this paper.

Yep, this is why I've not looked for a throw/blanket, because they're often heavy, woven. Looking for something light and thin too.

I did think about this. I think this is similar to what hotels do in warmer countries. Just a flat sheet to sleep under.

Does anyone not use a duvet in hotter weather? If so, what do you use instead? I can't seem to find any clear alternatives. A flat sheet? Some sort of blanket? I don't really want to get a summer duvet as we're short on space.

I've seen this elsewhere online with people stating that PEM is unique to ME/CFS whereas PESE is a more general feature of other conditions. However, scanning this paper, I'm not even sure that's what the authors are doing as they've not clearly stated that they are two different things, and in...