Changes in blood metabolic profile during repeated cardiopulmonary exercise testing (2xCPET) in ME/CFS patients
Henrique Chapola, Katarina Lien,, Sissel Dyrstad, Per Ole Iversen, Karl Johan Tronstad
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ME/CFS is characterized by post-exertional malaise (PEM) and delayed...
The proteins enriched in the neutrophil pathway at baseline were PSMA5, RAP1A, KPNB1, TXNDC5, RAB7A and at 15 minutes post-exercise were ERP44, RAP1A, GSTP1, DSG1, TXNDC5. All lower in ME/CFS EVs.
Neutrophils were a hot topic in the study from a few days ago:
Preprint Charting the Circulating...
Bio-IT World: 'A Practical Precision Medicine Approach to Complex Chronic Diseases'
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'Based on unpublished data, the “strong expectation” of investigators is that all nine of the genes thought to be common to ME/CFS and long COVID will be a reproducible finding. The All of Us dataset used...
Ah yeah, YouTube guessed meltsey and Claude guessed that meltsey meant ME/CFS from context. I tried another method of getting the auto-generated Norwegian subtitles and asking Claude to do the translation as well. I was adamant that it should not change content and to put anything it wasn't sure...
I used this website to get those auto-translated subtitles, then I asked Claude Sonnet 4 to format it nicely and fix any typos without changing the content:
Edit: Better translation below.
HLA-C has the 39th highest fold change out of the 7326 aptamers they tested (logFC = 0.35). Not significant though (p=.19, q=.45).
Here are all the ones they tested that mentioned HLA:
Edit: Mistyped the q-value.
Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response
Serena Fineschi, Joakim Klar, Juan Ramon Lopez Egido, Jens Schuster, Jonas Bergquist...
Email from IACFS/ME:
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Dear IACFS/ME Supporters,
We would like to share with you the following message from Caroline Kingdon, RN, MSc, at the UK ME/CFS Biobank.
If you have any questions please send them directly to the Biobank via the links below.
Sincerely,
IACFS/ME...
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