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I think the aerobic exercise is just being used as a challenge, to see what happens when people with ME/CFS do physical activity. Just looking at BDNF, it seems that the protein might have a role in our symptoms, and that exercise should increase the expression of the gene. So, at first...

Just in case we have any members on the eastern coast of the North Island who haven't caught up with the news yet, there is a serious tsunami warning with evacuation notices.

An active blog focused on claims relating to CBT and IAPT, by Dr Mike Scott. http://www.cbtwatch.com It describes itself as 'An Independent Mental Health Watchdog and Discussion Forum' It's not anti-CBT, but is anti-IAPT. There's a lot of well referenced material there that is likely to be...

It is a great article @mango. Good job Agnes Arpi.

For example: Circadian clocks and vascular function https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848505/ So perhaps the patients were sampled at a different time of day than the controls. And/or the patients might have, on average, a delayed daily schedule compared to controls. That might...

I wonder how variable the two measures are for a single person with ME/CFS over time. As in, perhaps PEM changes the scores? Also, maybe circadian variation - and timing of tests might be a factor?

I haven't read this paper yet, but, from the abstract, it seems to be evidence against the idea of dysfunctional NK cells. Swedish and Norwegian researchers.

From the link for the webinar:

That would be the smart approach - the draft guideline still had plenty of scope for CBT and exercise. If I were them, my strategy would be to divide, and conquer most. i.e. largely cede a small minority of patients that have an illness that has a bit of a biological cause - but CBT and...

Yes, he's a nice man, and he doesn't downplay how hard he found having 'chronic fatigue'. It's great that he is willing to front up and say he has the illness. But he's a bit of a double edged sword as far as being the national celebrity spokesperson for ME/CFS. Coming from a high performance...

With the constraints that the illness imposes and the great yawning void that is the need for advocacy, I don't think it's sustainable for each region in NZ to run its own charity, complete with comprehensive services such as moderated forums and independently developed resources. It's too easy...

Yeah. The TVNZ program tonight was exactly as I expected - this program very much covers issues in soundbites. So, the information is superficial, presented by two young doctors with nice white teeth and bouncy personalities. The item was pretty good at getting the message across that CFS is...

The article is well-meant, even good in places. But I can't make sense of this. They seem to be suggesting that their unifying hypothesis is 'viruses (an acute infection or a reactivation of viruses) causing ME/CFS symptoms'. As hypotheses go, it's, well, pretty vague and limited. What about...

Likely selection bias. Cherry picking Null result. Sticking with the planned conclusion despite a null result, with a spin that will inevitably make mothers feel guilty and reduce the need for proper biological investigation of the causes of the conditions (which could lead to a better...

I think the evidence for the double spike in ME/CFS is rather weak. Although, it certainly would be interesting to know if there is any age pattern in Long Covid incidence that isn't directly related to Covid-19 incidence.

This protein expression stuff is exciting I think, and it looks like we have a number of teams interested in it. @DMissa I am tempted to leap into googling each gene where expression has been found here to be down regulated, to find out what it does. I've been looking at the Human Protein...

In the wake of the pandemic: preparing for Long COVID (2021) https://www.euro.who.int/en/health-...of-the-pandemic-preparing-for-long-covid-2021 discussed on the WHO thread...

That makes as much sense as deciding someone who has been in a car crash and now has a damaged spleen and a broken leg can only ever be labelled as 'car crash victim with broken leg', because saying that they have 'damaged spleen' as well would prevent the broken leg being identified. And that...

I've been searching to see if anyone has been looking at Long Covid with animal models. I haven't found any so far, but this paper at least acknowledged that it will be something to prioritise once vaccines are rolled out. Animal models of COVID‐19 hyper‐inflammation, 2020

I feel sure that there must be similar post-infectious fatiguing illnesses in animals; it seems highly unlikely that humans would be special in this. If we could find just one, it could give us an animal model. There's this 2021 report about a ferret model for Covid-19 - Dose-dependent...