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Here's a 2020 BMJ paper on this: https://fg.bmj.com/content/early/2020/09/22/flgastro-2020-101436 Bile acid diarrhoea: pathophysiology, diagnosis and management

BAM! to ideas of functional illness (Bile Acid Malabsorption, that is.) BAD (Bile Acid Diarrhoea) Seems like the detailed physiology is fairly well understood: Of course, every participant who didn't qualify for the Type 2 BAD diagnosis was left in the functional illness bucket. Cos...

There's the issue of how long recovery might take, and if it happens, and then of course also the issue of if 'normal' is actually attained in recovered cases. That is, how complete the recovery is. It might be that some infections leave everyone slightly damaged, but the level of damage can...

The only thing interesting about that diagram is how someone could go to all that effort with the coloured arrows, and the little pictures of the bodily organs in case people weren't sure what they meant by 'heart' etc, and still have 'score throat' listed as a symptom.

This thread How Might Ativan, Clonazapem Increase Strength? seems relevant, at least for answering the first question I had, which was 'is there fairly strong anecdotal evidence of lorazepam improving ME symptoms?'. Several members (at the severe end of the ME/CFS spectrum) have reported...

To me, it seems like catatonia is more like a symptom or group of symptoms than a disease. A sort of shorthand for ‘someone not acting normally’. I don't think I have any of those signs, although no one has tried to 'adjust my body' lately. It's entirely likely that I might resist that, and...

Here's the Sci-Hub link: https://scihub.wikicn.top/10.1016/j.amjmed.2005.07.047 :) The BPS researchers in New South Wales, Australia continue to be keen to research the psychostimulant Modafinil. And, as far as I am aware, the Royal Childrens Hospital in Melbourne continues to prescribe...

I've added a thread for it here: Does Methylphenidate Reduce the Symptoms of Chronic Fatigue Syndrome?, 2006, Blockmans et al

Does Methylphenidate Reduce the Symptoms of Chronic Fatigue Syndrome?, 2006, Blockmans et al There's this 2006 Belgium study.

Edit - note that this is an old study. https://www.sciencedirect.com/science/article/abs/pii/S000293430500656X Daniel Blockmans, Philippe Persoons, Boudewijn Van Houdenhove, Herman Bobbaers Belgium Abstract Purpose Chronic fatigue syndrome is a clinical entity consisting of prolonged and...

I can't access the paper. But it's interesting to see this in darrellpf's post, A very recent study that looked at cytokines in 34 POTS patients found that they had high levels of IL-21. Inflammatory Biomarkers in [POTS] with Elevated G-Protein-Coupled Receptor Autoantibodies, 2021, Gunning...

For those of us who didn't know what an 'elite controller' is: (I think there's a joke somewhere there about the elite controller being the Fat Controller (through lipophagy), but I'm too tired to work out what it is. Or perhaps there isn't. )

I guess if Crawley is doing this, she has less time to be promoting the Lightning Process or other some other 'think yourself well' scheme. If she's using a pharmaceutical company's funds, she isn't using up government research funds. And there's an outside chance that some child with an...

I'm not suggesting that it was deliberate cherry picking, and maybe that's not quite the right word, but that the effect of such a significant amount of missing data was probably to produce a more positive result.

Given that it has been suggested that I have been too negative about Ablify, I want to try to explain my reasoning: Over a quarter of the participants either didn't improve or worsened for every outcome, or had side effects that led to withdrawal. Think about that - coming to a specialist...

A number of posts discussing attitudes to varying levels of evidence for treatments, and how the nature of a treatment might affect our level of scrutiny and acceptance of it on the forum, have been moved to this thread: How do we discuss science and medicine on S4ME forums?

That's not always true. The PACE study was flawed, but we can still conclude that it provides fairly good evidence that CBT and GET do not cure CFS, or even markedly improve it. The Ablify study had a number of flaws that worked to amplify positive outcomes and yet the reported findings were...

Sorry to hear this, gastro problems are so terribly wearing, making it hard to get in enough nutrients. I hope spring does bring improvement. I and my children have had such symptoms at various times in our illness. A few thoughts, probably on things you have already ticked off the list: I...

Yes, the idea doesn't hold up as being among the most important factors when you look at the epidemiological evidence. MS is common in New Zealand relative to the rest of the world, and yet life in New Zealand is generally far less traumatic than in many countries with much lower rates of the...

SciHub link Note this improvement on the placebo, versus the 30% reported improvement in the fatigue of patients in the recent open-label Ablify study. Certainly, the short time period will have been a factor, as it is fairly easy to hope that you have improved over just a 2 week period. But...