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Interesting - I didn't even know it existed. Anything that's publicly funded should meet minimum standards yet as @Hutan @Caroline Struthers and others have highlighted, it seems they don't meet even the most basic standards - it seems that all of the ME/CFS research on CBT and/or exercise...

I'm laughing - thank you.

@Caroline Struthers provided a good example here* and yes it's to be expected --- *https://www.s4me.info/threads/independent-advisory-group-for-the-full-update-of-the-cochrane-review-on-exercise-therapy-and-me-cfs-2020-led-by-hilda-bastian.13645/page-80#post-390317 Yes, you need to design...

When you use subjective outcome criteria (questionnaires) and the study is inadequately blinded then you will get a non-zero +ve effect. @Jonathan Edwards described this as "placebo" and it reminds me of the Hawthorne effect*. However, if you look at the studies of actimetry (objective) versus...

Yea easily subverted by the mates club.

It would indeed be possible and it would be an good idea since there may be folks who would look at the GRADE/Cochrane analysis and could publicly challenge it. Yes, if NICE are going to use Cochrane/GRADE then NICE should work with Cochrane to try to improve the Cochrane/GRADE assessments. I...

You're probably right but @Jonathan Edwards set it out very simply* and @Brian Hughes set it out in more blunt terms --- EDIT there is a better way to do studies --- they just don't seem to be motivated to do better work. Maybe the funders (NIHR, MRC ---) should be our target; I think someone...

Don't know if I'm answering your question here. I think moderate quality evidence that the effect of the intervention was non-zero. However, if you look at the fact that the trials were unblinded and used subjective outcome indicators, then the claim that these trials provide ---moderate...

I've only skimmed this but it reminds me of what @Brian Hughes has been saying i.e. these studies simply replicate previous flawed studies (un/inadequately blinded plus using subjective outcome indicators - questionnaires). Yes, why isn't this designed out at the beginning and how come the...

Hi folks, on September 21st I emailed NICE* to express concern re their use of Cochrane reviews to evaluate evidence; referring to the recent NICE review which referred to "low" or "very low" quality of the studies - Cochrane had evaluated as "moderate" [Myalgic encephalomyelitis (or...

Might this explain some of the statements/reactions from members of the Royal Colleges to the new guideline?

Thanks for this - pretty incredible. So cognitive processes can bring about---changes in the immune system, nervous system and hormonal system I suppose it would be too much to expect evidence to support that statement; although I suppose it depends what you mean by evidence.

Obvious person to alert is @Simon M but there may be others. Think the recent video update from Chris Ponting mentioned that the ME/CFS GWAS study (DecodeME) could eventually move to whole genome sequencing study i.e. using the DecodeME samples (correct?).

Interesting. Is there a reliable test for ---accumulating lactic acid in their muscles? Plus, as you've pointed out - where's the data/study?

If you check out some of @Jonathan Edwards comments then you'll see that there's no evidence of classical autoimmunity in ME/CFS though there is support for a trial to look for autoantibodies. There's a thread here* re a new method to detect autoantibodies [REAP] - Aaron Ring at Yale is doing...

Just to confirm. the petition closes on November 9th 2021?

I really don't keep up with Cochrane/Grade --- Basically, as @CRG has set out, NICE is responsible for preparing the guidelines --- if something inappropriate is incorporated into a guideline (dodgy assessments by Cochrane or whatever) then --- NICE is responsible So basically NICE can use...

Thank you very much for the advice and encouragement; I couldn't register via my laptop but it worked OK on my phone. I followed your advice, re only using the special character listed, i.e. not a number - I used 10 characters but I it would work with 8 - 15 (as suggested). Now that I've...

Won't accept my password - suggestions?

Are you going to consult on the identified options ----?