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    Multi-‘omics of gut microbiome-host interactions in short- and long-term myalgic encephalomyelitis/chronic fatigue syndrome patients, 2023, Xiong

    Yea consequence or cause? If it's consequence then presumably you need to understand what's upstream. If it's cause then it's more interesting; Chris Armstrong (from memory) put forward the theory (webinar 2015?) that gut dysbiosis was maintaining the disease state - bi-stability if you like...
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    NHS England web pages on ME/CFS

    I barely remember reading it but my impression was that it was way out of order. NICE is an independent body and its role is to analyse the evidence, which it has done, and prepare the guideline. NHS England should not be making these comments at this stage of the process (in fact I've a feeling...
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    I need a good summary of the problems with mind-body theory

    I've participated in an anxiety & depression GWAS study run by Ulster University (Northern Ireland). Obviously that's an attempt to understand underlying (genetic) predisposition ---- and genetic traits that may protect? So yea anxiety seems to be poorly understood ---- the whole...
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    NICE ME/CFS guideline - Stakeholder submissions to the draft and NICE responses - published 29th October 2021 - discussion thread

    @Arnie Pye posted me a link to this* North Bristol NHS Trust - CFS/ME Service posted this re Professor Jonathan Edwards: "“Some exercise studies show objective changes in indices of fitness but that does not necessarily imply a reduction in illness or disability”, domains which are typically...
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    NHS England web pages on ME/CFS

    Haven't read the posts here but I assume you've noticed the response from "NHS ENGLAND & NHS IMPROVEMENT" to NICE* *"Paul, I have read the new guideline. To me, it reads very much like the previous guideline with little change in emphasis and doesn’t really address the key criticisms...
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    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    If they had done then their comments may have been minuted and the response (probably setting out that the comments made no sense) would also have been in the minutes. Possibly an FOI would have led to the disclosure of those statements ---- so best to say nothing that makes you look stupid...
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    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    Stop bragging everyone will be trying to get blocked --- badge of honour!
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    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    Interesting* @Nightsong I haven't followed this closely but NICE reviewed the evidence for CBT & GET, re ME/CFS, and found it to be "low" or "very low" quality; logically there should be a review of "other conditions including chronic pain and fibromyalgia" i.e. which rely on these...
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    UK NICE 2021 ME/CFS Guideline, published 29th October - post-publication discussion

    I think Paul Chrisp has made the classic mistake of management --- he hasn't been involved in the development of the guideline so he should shut up and let the people who were (and who impressed a challenging audience) speak. Maybe there's a case for the management class to do the dark arts of...
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    Publication of the NICE ME/CFS guideline after the pause (comment starting from the announcement of 20 October 2021)

    I guessed they'd get the guideline out quickly but no I hadn't heard that.
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    Publication of the NICE ME/CFS guideline after the pause (comment starting from the announcement of 20 October 2021)

    That looks like a very good strategy but is there any indication that it will be published in the second week of November? I wouldn't be surprised if NICEs strategy is to publish it as soon as possible - let's face, it this has caused NICE enough hassle already! On the plus side, NICE appears...
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    Publication of the NICE ME/CFS guideline after the pause (comment starting from the announcement of 20 October 2021)

    Yea I've no problem believing that Psychiatry diagnosis can be changed; lets face it, there really is no understanding of the underlying cause, so it's sticking labels on the presentation. I vaguely recall a post where @Jonathan Edwards set out his experience as a young medical student -...
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    Publication of the NICE ME/CFS guideline after the pause (comment starting from the announcement of 20 October 2021)

    Yea Northern Ireland has no specialist service to the best of my knowledge. @Keela Too However, I'm hoping that the changes for the better in the UK will e.g. be picked up elsewhere (European Union is one example) @Michiel Tack
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    ME/CFS services in the United Kingdom

    I'm surprised that an NHS clinic would not stick to the guidelines - OK strictly speaking the new guidelines haven't been adopted yet. Perhaps a route to challenge this would be for a charity to contact the health trust and ask if this is within the new guidelines? You might find that the...
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    Publication of the NICE ME/CFS guideline after the pause (comment starting from the announcement of 20 October 2021)

    Regarding "I assume also it is up to commissioning groups/bodies to specify compliance with guidelines when they are contracting for services." I assume that following the current guidelines is the only defensible option so it may not be necessary to spell it out; also the contract will probably...
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    Publication of the NICE ME/CFS guideline after the pause (comment starting from the announcement of 20 October 2021)

    I assume the trusts, who are responsible for delivering care, are responsible for implementing the guidelines. NHS England [English National Authority] has responsibility - i.e. as the Authority which commissions care via the trusts - and the body which oversees the NHS system in England - so I...
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    Publication of the NICE ME/CFS guideline after the pause (comment starting from the announcement of 20 October 2021)

    It was a (failed) attempt at humour - I recall her reaction at the News Night feature re Paul Garner --- I don't recall it +ve myself.
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    (Not a recommendation) Alastair Miller on CFS

    I noticed this on MEpedia. Guess what he worked at Liverpool School of Tropical Medicine --- where, you've guessed it, Paul Garner works --- @Trish might provide the link to the News Night interview but I'd caution against watching it. I see Alistair was "Principal Medical Adviser from...
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    Evidence based care for people with chronic fatigue syndrome and myalgic encephalomyelitis, 2021, Sharpe, Chalder & White

    What's worrying is that there may well be customers for the unproven products they are selling e.g. a purchasing/commissioning officer who listens to their sales pitch and doesn't research further----.
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