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There's a video of a joint presentation by Chris Pointing, + someone from the UK biobank(?), which showed the results of a Genome-Wide Association Studies of Hypertension(?). The genetic markers were clearer with larger numbers - think they went to 500K. So maybe the more studies (more data) the...

Maybe Blair wants to be "explainer in chief" - rather than owning up i.e. we don't have the solutions at this point.

That seems very insightful (hopefully they're not reading this) can they sneak in i.e. under the revised guidance (and continue to make money out of the problem)?

Yes I've heard that much early psychological research, which was conducted by researchers who had experienced the Holocaust, was reliable/sound. This came up in the context of discussion of making up research findings - scientists cheating [BBC Radio 4 program?]. I think the point that those...

Go for the website - should not be used for clinical decision-making or just abbreviate - should not be used--- I gather there are folks teaching PACE i.e. as in how not to do a trial - maybe put this up as teaching material --- how to deceive - a masterclass in manipulation

Actually if you had noting better to do this is an entertaining read - OK possibly despairing, incredulity --- couple of random paragraphs* --- "Resources with universal relevance" I think "Global" is what they are aiming for. Aside from politics/government propaganda I doubt there much use for...

This shit should be put up for an award - based on a few seconds I found this gem "The learning resources complement and facilitate critical thinking teaching and scientific reasoning in other areas." Who could possibly object to that - a thing of beauty - aspirational, sun light uplands ---...

Probably true i.e. the % of people who've had an MRI is probably quite low. My wife has syringomyelia and my impression is that an increasing number of people are having MRIs and being told they have an abnormality - often they are not symptomatic - generally wait and see I guess i.e. no...

Some thoughts - what is the abnormality [present at 80% or 90%]? have the looked at controls i.e. to establish what "normal" is? if you sent them a set of MRIs could they identify ME from healthy controls? Like you, I'd expect that a lot of people with ME would have had an MRI; therefore, a...

If you're wondering about NICE dividing studies into mindless sub-groups then it might be that those doing the sifting don't have much insight. I did wonder if one reason was to refer to every possible study. The easy grounds to judicially review something are procedural grounds e.g. that they...

Interesting --- at least there's a positive outcome for the ME community.

Think that's the problem "They do it by employing the right level of expertise to assess the new tech in the first place" ---- or in the case of NICE that doesn't appear to have happened re the original ME guidance. My point was that Doctors like @Jonathan Edwards when they are dealing with...

Exactly i.e. "NICE are supposed to make use of the people who know how to do it, surely". OK if it's difficult to get hold of the experts, understandable as they are treating patients, then an idea would be to use a screening tool - but not when it doesn't work [GRADE]! I have to say that you...

Re "IDO inhibition", from memory Robert Phair* mentioned that there was a trial of a drug which inhibited IDO1 i.e. in people who were terminally ill with cancer. The patients refused to continue the treatment because of the fatigue it caused. *One of the OMF Community Symposiums I suppose.

Thank you very much for your insight @Snow Leopard.

Yip interesting to know if this is relevant to ME or could be. @Jonathan Edwards post re immune dysregulation(?) here, came to mind: https://www.s4me.info/threads/me-cfs-funding-worsens-as-nih-maintains-status-quo.12949/page-2#post-228586 Neil McGregor gave a talk, at an OMF Community...

It seems like the best you could do is arrive at some sort of basic rules re what is acceptable/unacceptable e.g. @Simon M had a basic (but sound) rule "subjective outcomes only acceptable in blinded trials" "objective trials acceptable in unblinded trials". However, I'm not sure you could...

I wonder if they even used a good reference method for B12 deficiency (i.e. methyl malonic acid). Also, did they try the technique @Jonathan Edwards has been highlighting i.e. dose response curve [adding B12 and seeing if it improves symptoms]?

Pray what are these "specialist clinics were genuinely excellent" dispensing and has it been validated [and not by GRADE]? Or is it just the fine Doctors who lead them?

I think the problem with GRADE is that it's not that easy to define the dependent variables i.e. measure X, Y, Z --- and if the study is flawed then the number is above "n" --- bit like the meaning of life the universe and everything 42! Theoretically you should be able to produce the model but...