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Way above my head too. I'm not sure if this post by @Jonathan Edwards is in any way related to this publication [they both suggest immune dysregulation I guess]: https://www.s4me.info/threads/me-cfs-funding-worsens-as-nih-maintains-status-quo.12949/page-2#post-228586 The other thing is that I...

Perhaps broad criteria are OK in a biomarker study; if you filtered too much then you could exclude people who provide insight into the disease mechanism.

Seems to provide evidence for going with a single dose --- reduction in hospitalisations 95%? I wonder if this will encourage the the UK Westminster Government to further delay second doses i.e. to get more people a first dose. Still, only sure approach to avoid severe illness/death is not...

My prejudiced view is that some of these peoples social circles/establishment friends might be avoiding publicly supporting them --- but maybe I'm wrong on that!

With a bit of luck: fingers have been burnt. Including the public servants who were involved in this [PACE] project and, indeed, it's subsequent adoption as Government policy; and politicians will be aware of the risk of associating themselves with these dodgy psychosocial theories - can't be...

Here's an extract but it's all pretty daming. “Although we originally planned to use actigraphy as an outcome measure, as well as a baseline measure, we decided that a test that required participants to wear an actometer around their ankle for a week was too great a burden at the end of the...

I wonder if that could be highlighted in the media i.e. if the objective activity monitoring was dropped - pretty damning! By the way who dropped the activity monitoring i.e. the "researchers" or the civil servants/Government? If there's a link to the specific text then I'd be interested. Can't...

But surely "all studies gave the same direction and because the observed heterogeneity (80%) was mainly caused by a single outlier" suggests that in an unblinded intervention, with subjective outcomes (questionnaires), the Hawthorne effect is consistent - people respond positively to attention...

Thank you. "meaningless games with words and statistics" --- "It is not clear that patients' self-perception has actually changed, or just their scoring behaviour, which are two different things." seems to sum it up - damming. EDIT - if the intervention doesn't work, and the exercise...

So a study which found a negative outcome [ability to return to work] was adopted as the basis for Government policy. I'm tempted to say unbelievable - but then it (unfortunately) is believable. I've previously highlighted the old internal joke about the Governments official line being "evidence...

The other thing is that there doesn't appear to a good reason to rely on crap studies/methodology i.e. to assess whether an intervention works. E.g. Fluge, and Mella, used activity monitors to assess rituximab. So rather than defending poor studies they could spend some time looking at objective...

Don't know much either but transcription means making a protein - post transcription means the protein is altered after transcription. I kind of recall a talk Jonas Bergquist did a few years back i.e. on proteomics. Basically the body make a remarkably few proteins (maybe 40K) but post...

IO think Karl Morten used muscle cells (& the seahorse - check his talk in New Zealand a few years ago).

Yea I immediately thought of Bhupesh Prusty's work. I'm not suggesting that you assume that mitochondrial fragmentation is in fact a biomarker for ME. Bhupesh has been looking for a biomarker for mitochondrial fragmentation --- tome this paper is looking at the same problem from a different angle.

Bupesh Prusty's work comes to mind when you mention dUTPases - but I've no idea if that is relevant to this conversation https://pubmed.ncbi.nlm.nih.gov/32327453/

Excuse me coming back to this @Snow Leopard I'm thinking of the interests of the ME/CFS community here! Do you think: "---vascular and endothelial function, particularly peripheral muscular (and brain) capillaries ---" would be useful for ME/CFS?

Bear in mind @Andy that there's a review of questionnaires versus activity monitors (it's available somewhere on this site) and it found questionnaires overestimated activity; the activity monitors used were pretty sophisticated [time spent upright etc.]. This publication might be interesting...

There should be some mechanism for the patient community to input into the policy re funding research. E.g. in this case to highlight the previous (negative) experience and how things should be done now. Your suggestion re "vascular and endothelial function, particularly peripheral muscular...

I work at a junior level in policy (unrelated to health) and it's a bit like brain storming --- creative ideas i.e. for responses. I'd hazard a guess that the (healthy) person who wrote this was just churning out some fancy words --- the reality is a matter for others, who are unwell, to live...

Unfortunately your concerns are entirely justified and eloquently summed up by @Jonathan Edwards "The vultures are circling - and babbling as they fly."* Jonathan has also highlighted "the problem with understanding the illness is mostly that it is too difficult to know where to start. People...