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Wow, that's solid reporting. The way they portray pwLC is the same as how people with other severe illnesses are portrayed. The first scene, for example, features someone talking their morning pills. There are few small negatives I notice. One blemish is that they try to compare the prevalence...

I'm disappointed they didn't break down their findings by vaccination status. Eyeballing the chart, it seems like vaccinated outcomes are similar or even worse than vaccinated. We know vaccination reduces the risk based on studies designed to do that. My guess is that this study can't give...

I'd recommend against referring to people with long Covid as "otherwise healthy". "Previously healthy" or "without comorbidities" would be more in-line with how other conditions are discussed. It somewhat connotes that the illness either isn't real or isn't serious. "Besides having...

So, a quarter of children with a severe, chomic illness had depression? And the sicker they were, the more emotional distress they experienced? Exactly what we would expect. It's a Crawley paper though, so I imainge they're trying to claim that depression is a factor in ME.

Excellent example of how a supposedly harmless, but ineffective, treatment can indirectly cause harm.

Finding a correlation between PTSD and chronic illness is not surprising. The ACEs study found that childhood trauma raises your risk of many illnesses, including those nobody believes are psuchosomatic, and can take decades off your life. A likely mechanism is that trauma makes it difficult to...

*Record scratching sound* That's a dramatic change in tone. Also, it would be hard to prove pacing actually works, due to the same issues that plagued PACE. A slight difference is that we market pacing as a symptom management strategy, not a treatment.

A smart and balanced article. The title was ambiguous, but fear not. They're not comparing patient advocates to non-doctors pushing hydroxychloroquine--they're comparing people pushing GET to it, because it's unproven in long Covid. The gist of the article is that PACE was pretty bad, and that...

I also actively want my body to be used for research, assuming knowledge about ME is still scarce once I die.

Very deep and interesting read. Summary of what I read so far: Microglia aren't either resting or activated as many assume. They're constantly active, but play different roles at different times. They are highly receptive to their chemical environment, so subtle signals can change their...

Develop the nanoneedle into a commercially available test for ME or prove conclusively it doesn't work. If we succeed, we'd make ME easily diagnosable and prove it's physical. We'd also have a platform for in vitro research--we could try different drugs on the blood of pwME and see if it makes...

Overstating their findings and potential undisclosed conflicts of interest? Very disappointing to see when our lives hang in the balance.

True. I experienced PEM for three years before I heard the term "post-exertional malaise."

We seem to have missed the fact that this paper is a milestone: It's the first completed, rigorous trial of a long Covid treatment I know of.

It's very mixed, a little over half of commenters leaning towards biological and the rest towards psychological. Insightful excerpts from the biomedical comments: A reply to a comment discussing how pwME are angry at BPS ideology: The most insightful one recognizes both the biological nature...

I'm sure there's way more pieces to this puzzle than levels of chemicals.

Why research the pathology of a disease when you can just say that music therapy works and declare victory? heh

They found something new in a small study...that a whopping two people with ME have elevated levels of ATG13 and that microglia don't like it. This is a brainstorm, not a real hope. While their research appears novel, all scientists should present their findings realistically, especially if...

The main problem was that they tried too hard to represent "both sides." They also called it "chronic fatigue", only mentioned PEM once, and covered the BPS model in details while not giving any of the evidence it's biomedical--just that doctors believe it is, not the actual findings. And they...

Kudos to the authors. They interpreted their answers honestly instead of trying to puff them up. It's not a positive answer...but I will welcome any solid answer in this disease, because even "no's" get us closer to the truth.