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So there are four groups control group model group with no genetic changes NC (Model) model group with the PK2 gene knocked down/with reduced expression (Model + PKM2-KD) model group with the PK2 gene over expressed (Model + PKM2-OE) The title and hypothesis is “PKM2 accelerated the...

There may be a contradictory findings or wording in the paper. Something which was flagged in one of my LLM generated summaries I listen to and I think can be seen in the abstract. I need to check the paper to confirm though and can’t quite get my head around it atm but… Here’s some quotes from...

CFS is persistent fatigue so inducing persistent fatigue is CFS is a sort of logic I guess? They do seem to have invented a new way of torturing mice anyway. While I’m very wary of their definitions of this being CFS let alone ME/CFS, trying to understand induced fatigue seems a fair enough...

I feel like my original explanation downplayed it or only explained the ‘lighter’ forms of it. Because reading others descriptions I also agree with a lot said. Zopiclone, there’s an interesting one that I’d had when younger and suffering from mental health issues and staying awake for days...

Maybe a more succinct response would be.. Maybe more people get better or are asymptomatic in some way so we don’t record them as having ME/CFS. But when we know more we’ll find they did have this same thing but something took a different path. Like, loads of people get Flu but only some get...

That’s true @Trish It was part an idle counterpoint. So maybe not worth thinking too much about. But I suppose I was also thinking about self selection. We’re the ones that don’t get better. I guess that’s what ME/CFS is but maybe that’s not all it is? We know people get better earlier, we...

Physically and mentally exhausted. But my body and mind are somehow not restful (I’m cautious to say not relaxed but that could describe it too, or maybe alert, primed) while awake or asleep, with sleep being difficult or broken/lower quality. Exhausted and restless may be another useful...

A trivial but recent (and common) example. The effort of sitting up and trimming my hair or beard with clippers. Sometimes it goes okay, other times it’s too much and a few hours later I can feel the heaviness and aching spreading through my whole body, not just arms or core that had been used...

I also used some Deep Research summaries and Audio Generated summaries from Google Gemini, happy to share these too although I understand there are mixed feelings on ethics and accuracy of these.

I’ve been reading/listening to lots about the immune system, particularly B and T cells. And thought it may be worth sharing some links to info I’ve found useful. If others have useful resources please chip in! There’s a lot of sources here and duplication, I found reading/listening to...

That’s a great way of putting it @Kitty and I absolutely agree that things which may on the surface look it, don’t necessarily contradict each other.

What if we’re the rare ones and those recovering or switching are the norm? We don’t really have the data to say which way round things are. Or if people ‘recover’ without ever having been bad like us. Maybe we all had something for years before we thought we did? The idea of a permanent...

That they’re developing a remote platform and using tools like the Ouura ring and GripAble device are interesting. Being able to have remote studies and gather information will I think be important to running more studies more efficiently and involve people who are housebound. But the solid...

It was a generally interesting science story but the added elements of genetics and evolution ‘finding a way’ and doing unexpected things along with the metabolic and possibly future links with disease mechanisms made me think others here would be interested.

There’s also an article about this https://www.vanderbilt.edu/evolution/castiglione-lab-discover-horses-run-faster-by-ignoring-an-ancient-mutation-that-says-stop/ And it was discussed on this week’s Science in Action in the BBC World Service https://www.bbc.co.uk/sounds/play/w3ct5vfb