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Yes, the same two alleles that were risk alleles for ME/CFS in this other study: Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Fluge, Mella et al 2020 I feel like I must be missing something, because why was there never much...

Maybe. In theory this could mean people with ME/CFS have other HLA alleles that are good at presenting junk. But HLA alleles are different from regular DNA since there are very many possible HLA alleles, plus each person has several different alleles. So not having this gene doesn't necessarily...

Are you referring to a different gene in the main part of the study? This HLA part was looked at separately and they found another protective gene here (though they say they'll need to verify the association is correct).

Yeah, that could be good. They just have EBV, COVID, or other (columns are females, males, total, and total percent)

Well this specific allele from the study seems to protect against getting ME/CFS, which I don't think would fit with that. Maybe it's more like it's good at presenting a specific virus to T cells that is a common cause of ME/CFS and this fights the infection more quickly?

Just in case there's a connection, this other study found other suggestive (not significant after correction) protective HLA alleles (one of which, interestingly, it says, is protective against rheumatoid arthritis): Human Leukocyte Antigen alleles associated with Myalgic...

The paper says this, so that shouldn't be the case: "A1FREQ is the frequency of the effect allele in the combined cohort."

Made a thread here: https://www.s4me.info/threads/genetics-hla-dqa-05-01.45523/

HLA-DQA*05:01 Potential association from DecodeME:

I wonder how much overlap there was between the cases in DecodeME and the 10,327 cases in the UK Biobank.

Here are those 8 SNPs from the summary stats for GWAS 1: I'm confused about how the frequency in cases and controls separately for several of these can both be higher than the frequency combined.

It's certainly more significant in DecodeME than in the replication. It just didn't reach the strict threshold for genome-wide significance of p<5x10-8 so it wasn't reported as a candidate locus/gene. In DecodeME, it got p=2.48x10-7. In the replication, it got p=.027 (before multiple test...

I wonder if there will be an analysis that looks at only severe or only severe+moderate patients. Excluding mild still leaves you with 71% of the participants. Maybe there would be other interesting findings. Maybe larger effect sizes.

The full list of authors is at the end of the paper:

Just had a quick look at if any of the top 25 significant genes from Table S3 were significant in a few other genetic studies. I only have the genes saved from a few of the genetic studies that have been done, so I hope to check others too at some point, but I found that DCC and CDK5RAP1 were...

I think that's a good idea.

Also done. Let's get that whole genome study, SequenceME, or whatever else they've got cooking.

Yes, these specific parts: Edit: Seems to pretty much be all over the brain though.

Such a historic moment for ME/CFS and related conditions. Thank you to everyone on the DecodeME team, the patients, and everyone else who helped make this happen.

If you look at the table I posted a few posts up, it shows the frequency of the effect allele under A1FREQ. So for RABGAP1L, it says 0.325, which means 32.5% of the combined cases and controls had the effect/risk allele.