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This paper gives some data and background on eQTL not being as useful in identifying relevant genes as many anticipated. The missing link between genetic association and regulatory function | eLife Using diseases and genes were the mechanisms are relatively well understood, they found that...

For those with strength, courage and coding skills: I've noticed that the Dutch authors of MAGMA have a new method called FLAME. It combines multiple approaches to finding the effector gene within a significant GWAS locus using a machine-learning framework. Prioritizing effector genes at...

Regarding neuronal damage, there's this paper from last year that reported (slightly) increased Neurofilament Light Chain. Trial Report - Plasma Neurofilament Light Chain: A Potential Biomarker for Neurological Dysfunction in ME/CFS, 2024, Azcue et al | Science for ME This has also been...

Thanks for delving into this! It looks so complicated. I expected that there would be nice packages in R and Python that wrap this into a handy user interface and provide the correct reference data (for LD, for example) automatically. Quite disappointing that the workflow mostly consists of...

I think it would only need to explain why nothing has been found yet on the brain scans (mostly MRI) that have been done. Based on @SNT Gatchaman interesting example of chronic traumatic encephalopathy and others' responses that neural damage would still be possible, I think brain banks and...

This looks like it could be quite important, a new target for pain treatment?

Looks like a labelling issue of the graph. Here's what I got trying to recreate it. The high p-values belong to the SNPs with high MAF values, showing that it was mostly this group that reached significant hits. @Chris Ponting

Tried to recreate the plot using the whole dataset: I thought it started to deviate from the red line (which has a slope of 1) quite soon already from an observed -log10 p-value of 3. But the graph is a bit misleading because it is logarithmic so the vast majority of points are in the region...

Anecdotally I heard that the problems are mostly with bacterial infections, not so much with viral infections in severe ME/CFS. But I don't know if that is a consistent pattern.

Ah apologies. I think I mostly meant brain damage or structural changes, things you can more clearly see on brain scans.

But isn't that a peripheral neuropathy, one that wouldn't explain any of the core ME/CFS symptoms? And why would a injury that is not severe cause much more debilitating fatigue symptoms than the severe CNS injuries that are already known? If it is possible, it will probably have this special...

I don't understand why the prevalence of ME/CFS was so high in no-LC and control cases: how could it be 6.7% in people without Long Covid symptoms and 10% in controls? That's 20 times higher than common estimates of ME/CFS prevalence.

But wouldn't CNS injury be relatively easy to see on scans? And wouldn't we have the same discrepancy as explained in the introduction: that the fatigue in CNS injury is often less than in ME/CFS and if CNS injury was involved wouldn't it eventually be visible as ME/CFS severity increases to...

Ah yes apologies. I think I'm a bit confused because those low p-values shown in the graph are in purple and for the category: 0.01 ≤ MAF < 0.04, but I thought that the hits found had MAF > 10%?

Agree with this. So my counterpoint would be that the theory does not really state this, just that it is more likely that the key to ME/CFS lies in the neural pathway involved in generating symptom perception. Whatever else will be found in the future, it will probably have some special...

Perhaps AIDS (before it was adequately treated) might also be a good comparison to highlight. This is an example of a persistent virus that causes widespread immune dysfunction, a popular theory in ME/CFS and Long Covid research. Yet several physicians (Peterson, Klimas etc.) commented that...

By symptom burden I mean the fatigue/malaise/lack of energy and overall sense of feeling awful, not pain or suffering in general which in other disease can obviously be truly horrible.

I also get this lactic-acid feeling in my muscles and other patients suffer from weakness such as not being able to walk. But there are several reasons to think these are central rather than peripheral: due to things happening in the brain rather than in the muscle. 'oxygen tab gets closed...

I doubt it because we know what happens when those illnesses become more severe and it looks very different from ME/CFS. The pathology builds up and destroys parts of the body: muscles stop working, tumors develop, or there's brain damage, memory loss, joints get destroyed, organ failure, and...

Thanks for the comments @Grigor! To clarify: it was not my intention to minimize things or argue that peripheral pathology isn't possible in ME/CFS or that it is stupid to suspect or research it. Also agree that we still know very little about ME/CFS, that it hasn't been well researched in the...