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My bad, I was comparing the difference within ME/CFS to the difference between groups - will adjust my comment above.

I think that VO2 is VO2 divided per weight of the participant (so ml kg−1 min−1) while VO2_t is just the VO2 (ml/min), probably an error in the codebook. There's still something about these two values that don't add up because they should result in the exact same effect sizes but they often...

Thanks, got the same values as you. EDIT: this is an error see: https://www.s4me.info/threads/cardiopulmonary-and-metabolic-responses-during-a-2-day-cpet-in-me-cfs-translating-reduced-oxygen-consumption-keller-et-al-2024.39219/page-4#post-552976 I noticed that these average percentage changes...

Yes that was the difference. I forgot to include him because he had no valid data for HR. Yes I got the same result but made an error in writing it down in my table/overview. The different p-values might be due to me using: t_value, p_value = stats.ttest_ind(difference_MECFS, difference_HC...

Had a look but it seems that surprisingly only 10 participants did not meet the maximum effort criteria which are described as follows: Here's how I implemented this in my code (using Python) - hopefully somebody can check and try to replicate. df_original['HR_predicted'] = df_original['HR'] /...

Yes good point. I still have to look at these criteria so the values I reported above used all the data and will probably be quite different once I restrict the analysis to those who met the required thresholds.

I've tried to calculate the differences between CPET1 and CPET2 for each group and then compared them using a t-test. Here's what I got for the peak values: Most of the effect sizes are quite small and none will be statistically significant if one were to correct for multiple tests. Here...

I think it is splitting patients up in relatively active patients and passive patients. That's what the Dutch group of Bleijenberg et al. did. The focus for the active patients is then on stabilising their activity pattern and avoiding boom and boost while the focus for the passive group is on...

Seems that you are right: the legend under table 4 says: "%pred HRmax actual peak HR/(220-age)"

Thanks for the suggestion. Currently don't have plans to write about this in the near future but others have written about something similar (that Long Covid is not a functional disorder): https://www.statnews.com/2024/07/15/long-covid-not-functional-neurological-disorder/...

I think it might be a good idea but I also see potential problems. The vast majority of studies only report summary data (mean, sd, p-value) or in some cases just that the measurement wasn't significant. So the overview of data that is publicly available likely be a small subset of what has...

Thanks for spotting that.

There were also a couple of studies on catastrophizing by the research team of Jo Nijs. They have a background in pain research so that is probably why they had an interest in the concept. In two of their studies, patients had to estimate how much fatigue they would have following stair...

More info on catastrophizing and ME/CFS That first study on catastrophizing in 1995 was done by Rona Moss Morris. She also developed the cognitive and behavioural responses to symptoms questionnaire (CBRQ) which is the tool that has been used to most to measure catastrophizing in ME/CFS patients...

I think several forum members contributed to the Stanford project 'Rename Catastrophizing' from which I used several quotes. The project was posted in this thread: https://www.s4me.info/threads/rename-pain-catastrophizing-stanford-study-survey.15337/

Would be interesting to hear other thoughts about this: are there parts in the text that you disagree with or that we overlooked? There is some info that did not easily fit into the blog (otherwise it would be too long) and that I hope to post here in this thread in the coming days.

Twitter summary here: 1) New blog post about catastrophizing and why this term risks blaming patients by mislabeling their symptoms as exaggerated negative thoughts. 2) Catastrophizing has been a popular topic because it is one of the most consistent psychological predictors of adverse pain...

Catastrophizing, time to ditch the term? Catastrophizing, a cognitive distortion that amplifies the perceived threat of symptoms, has been at the center of cognitive-behavioral models of pain and fatigue. In recent years, however, researchers argued that the concept has been misapplied and that...

Yes I suspect the data refutes rather than validates previous finding on 2-day CPET. Haven't been able to analyse everything but it looks like the authors did two types of significance tests: They looked at changes over time (from day 1 to day 2) in each group separately and calculated an...

I think the problem might be that people would interpret PEM very differently.