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They are conducting a brutal war of attrition against us by ruthlessly exploiting one resource in particular that they have in lavish abundance and we have very little of – sheer stamina. An endless flooding of the zone with shit, knowing full well it takes an order of magnitude more effort and...

It is certainly effective at building their careers and empires. And of course they use problematic and outdated criteria. (Fukuda, & Reeves)

Indeed. The one thing they could do to help us is the one thing they are completely incapable of even considering, let alone doing, which is to get off our backs.

CBT for fatigue is "effective". Not by any robust methodology it isn't.

and the broader economy. Guess who the target audience is for this paper. Emerging research points to the early recovery period as a potential window of opportunity for intervention to alter patient trajectories, though evidence based treatment remains lacking. As we have been suggesting for...

With the extra possible/likely complication that a pair of neurons interacting may be a different phenomena to a few million interacting. Scaling up may introduce additional factors, that might also feedback into how single pairs interact.

In clinical trials, [the Shingrix vaccination] was shown to be 97% effective in preventing shingles in adults aged 50-69... Glad I got mine in my late 50s. Though did have to pay for it privately (thanks, Dad :hug:).

This whole approach looks more and more like just using technology for its own sake, to give the appearance of understanding and doing something. What the hell happened to people just learning to live with limitations at their own pace, without a whole lot of pointless performative...

Nice work. :thumbup: I can't see any problems with the basic hypothesis. It has the strengths of explanatory power, and parsimony, which I regard as critical in any good theory. Can you clarify what you mean by retardation in this context?

The virtues of humility, patience, prudence, courage, and hope mitigate the deprivations of CFS and promote well-being. Do they promote effective science?

Thus, as fatigability developed, the neuromuscular system experienced changes earlier than the actual behavior. While we found evidence for fatigability of central and peripheral origins, peripheral fatigue seems to occur first. If I am reading that correctly, it means that physiological...

And a lot more than money. Just as important, and sometimes more so, are power, status, reputation, face-saving, etc. Though a well above average income is always a powerful motivator too.

And the robust evidence for that (particularly for ME/CFS v. PTSD), including effect sizes and genetic commonalities, is...? Also, if it is "often" not always, then that alleged feature is not cardinal, and could just as easily be a misinterpretation, based on superficial similarities arising...

Pretty sure Glasziou was also heavily involved in the RACGP* guidelines on "incremental exercise' (aka GET) for ME/CFS, updated only last year. https://www.racgp.org.au/clinical-resources/clinical-guidelines/handi/handi-interventions/exercise/incremental-physical-activity-for-cfs-me...

Holistic Resonance Center :banghead:

Graded exercise is no longer routinely recommended. NICE explicitly recommended against it.

Seems like shameless lying and self-promotion is the main requirement for prominence in medicine these days.

Which is very close to the figure NICE reported. Hence any therapy recommended by the review has a high risk of harm.

highlights converging frameworks of dysregulated allostatic/stress responses in the context of predictive processing models of the brain. :rolleyes:

Psych diagnoses/attributions by clinicians usually tell us more about what is going on inside their heads then in their patients heads.