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  1. Sean

    Who is Simon Wessely?

    Don't know how long ago he wrote that.
  2. Sean

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    Not to mention whether or not patients looked down the barrel of that psychosomatic gun in a sufficiently manly manner. It's a nice compare and contrast. Leaving aside the question of how accurate that claim is, how is he reliably discriminating the critical issue of which causal pathway...
  3. Sean

    Reddit - Interesting posts on Reddit, including what some doctors say about ME/CFS

    Phew, what a massive arsehole. :grumpy: I see he is an orthopaedic surgeon, which specialty has [checks notes] absolutely nothing to do with ME/CFS. On the good side, the fact that he is so open and abusive and extremist means he will have precisely zero room for excuses when the time for...
  4. Sean

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    re: BMI effects on ALP My single data point is that my ALP has remained in the same range independent of my BMI (which was ≈22-25 for the first 25 years of ME/CFS, then rising slowly to ≈28-30 over the 15 years or so since).
  5. Sean

    Replicated blood-based biomarkers for Myalgic Encephalomyelitis not explicable by inactivity, 2024, Beentjes, Ponting et al

    I have persistently high ALP. It was first noted in my initial diagnostic workup for ME/CFS in 1989, and has been high every single time it was measured since then (including routine annual bloods).
  6. Sean

    New version of Covid, called NB.1.8.1 or Nimbus, doing the rounds

    Something I have done since the early days of Covid, when the basic symptom profile was becoming clear, was keep a few packets of the anesthetic type throat lozenges in stock. Have not had to use them yet. But still have them and replace them when past their use-by date.
  7. Sean

    [Book chapter] How Stigma Emerges and Mutates: The Case of Long COVID Stigma, 2025, Farrimond et al

    Plain English should be compulsory in the first year of all undergraduate degrees.
  8. Sean

    Preprint Understanding Neuroinflammation in Post-COVID-19 Syndrome: Biological Mechanisms, Diagnostic Biomarkers, and Therapeutic..., 2025, Martins et al.

    Nah. They will just twist the results to something like claiming that such findings are secondary consequences of avoiding activity, of the dysregulated psycho-neuro state, etc. Whether they can continue being successful in doing so is another question.
  9. Sean

    DWP assessor reveals 'sneaky' tricks used in PIP exam such as chair choice test

    Trust is the most important element of the clinical encounter. Betray that, and it is all over.
  10. Sean

    Neurodevelopment Genes Encoding Olduvai Domains Link Myalgic Encephalomyelitis to Neuropsychiatric Disorders, 2025, Lidbury et al

    Frank Zappa's take on it was: Without deviation from the norm there is no progress.
  11. Sean

    DWP assessor reveals 'sneaky' tricks used in PIP exam such as chair choice test

    Chairs with arms can be a problem for me as I discovered years ago that I can relieve back pain to some degree when sitting by keeping my arms folded across my chest (it helps lock the back into a relatively comfortable position, reducing the amount of active effort required to keep it there)...
  12. Sean

    WGS (whole genome sequencing) findings possibly linked to mitochondrial/metabolic dysfunction – anyone with similar results?

    And some, like me, who can get both effects (though not at the same time, it is either one or the other). Unsurprisingly the amount, but also the type of drink consumed, are also big factors, for me. When people say 'alcohol', in this context that needs to be defined precisely. Do they mean...
  13. Sean

    Neurodevelopment Genes Encoding Olduvai Domains Link Myalgic Encephalomyelitis to Neuropsychiatric Disorders, 2025, Lidbury et al

    Could be measuring the ability and/or willingness to mimic or conform to normative models of 'smartness'.
  14. Sean

    Thirty Minutes to Transform Care: A Mixed-Methods Study on Brief Psychosomatic Education for Unexplained Symptoms 2025 Sioni et al

    Okay, so they showed that clinicians can be more effectively trained to rote learn the unproven hypothetical model. And the benefit to patients of that is...? role-play illustrating empathic validation techniques Yeah, that's how empathy works and is learned. :rolleyes:
  15. Sean

    No Evidence for Unconscious Attentional Bias in People With Clinically Significant Symptoms of Functional Gastrointestinal Disorders:... 2025 Ejova+

    I wonder if the subjects (patients and controls) all being psychology students was a significant uncontrolled variable?
  16. Sean

    Chronicity rhetoric in health and welfare systems inhibits patient recovery: a qualitative, ethnographic study of fibromyalgia care, 2025, Cupit et al

    ...with a meta-analysis from 14 RCTs of telerehabilitation demonstrating statistically significant improvements... But not clinically significant? And on what outcome measures?
  17. Sean

    Unwilling or unable? Interpreting effort task performance in myalgic encephalomyelitis/chronic fatigue syndrome, 2025, Kirvin-Quamme et al

    Nice work, authors. Thanks. :thumbup: I do like brevity. :) Also, good you got in a mention of inadequate statistical power. That is an important limitation of the Walitt paper. Thank you. It is a disgrace that patients have to do the medical profession's dirty work for it, and all too...
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