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Hormonal alterations in adolescent chronic fatigue syndrome (2010, Acta Paediatrica) Their definition of CFS is 3 months of disabling fatigue:

Note that the case definition is only based on fatigue:

The paper refers to previous studies with similar results. Quotes from referenced papers: 15. Bakheit et al. Abnormal arginine-vasopressin secretion and water metabolism in patients with postviral fatigue syndrome. Acta Neurologica Scandinavica. 1993. [Article] [S4ME] 16. Wyller et al...

See new study with a similar finding: Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Endocrine Practice (Link to thread)

This is a 2010 study. See similar finding in a new study (note that antidiuretic hormone is a synonym for vasopressin): Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Endocrine Practice (Link to thread)

Hormonal alterations in adolescent chronic fatigue syndrome Aim The chronic fatigue syndrome is associated with alterations in the hypothalamus‐pituitary‐adrenal axis and cardiovascular autonomic nervous activity, suggesting a central dysregulation. This study explored differences among...

2017 paper. Note that antidiuretic hormone is a synonym for vasopressin. This paper was mentioned in a new study which found low vasopressin: Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Endocrine Practice (Link to thread)

Down-regulation of renin–aldosterone and antidiuretic hormone systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome Miwa, Kunihisa Background Central nervous system dysfunction associated with myalgic encephalomyelitis (ME) has been postulated as the cause of chronic...

I think that's specifically about excluding people that recently had COVID to make sure the association they're seeing is related to long COVID and not acute:

I think that's referring to this: So it's looking at pre-COVID social support's effect on the association between LC symptoms and lonelineless post-COVID. I also wouldn't necessarily expect pre-COVID advil intake to modify the association between long COVID and pain symptoms post-COVID, and...

Does this actually happen? The name ME has been around for decades, and I don't see people doing this play on words. People don't pronounce it "me", do they?

Why not if one considers loneliness a distressing long COVID-associated symptom that might be relieved by something like an online support group, in a similar way to how pain might be relieved by a painkiller?

Long COVID symptoms and loneliness: findings from the World Trade Center Health Registry Sisti, Julia S.; Packard, Samuel E.; Metzler, Janna [Line breaks added] Background Symptoms of long COVID can profoundly impact affected individuals’ functioning, including their ability to participate in...

Understanding how social determinants of health shape Long COVID outcomes: a rapid review of evidence [Line breaks added] Background Long COVID affects over 65 million people worldwide, yet the impact of social determinants of health (SDoH), such as socioeconomic status, race/ethnicity...

Characterizing T cells in the olfactory epithelium of people with hyposmia:

Analysis of mucosal immune dysregulation and safety and tolerability of endoscopic topical steroid therapy for long-COVID hyposmia: randomized, double-blinded pilot study [Line breaks added] Background Millions of people exhibit olfactory dysfunction years after acute SARS-CoV-2 infection...

There were no significant findings in this study after multiple test correction. They say so in the results: But the abstract and discussion don't mention this, and they instead say they found "promising" significant associations.

Thread for the documentary: Left out (Norwegian documentary on ME)

They say high electrolyte content due to low vasopressin might lead to over-excitability of neurons.

Brilliant write-up, as always. What an asset you are to the ME/CFS community. --- Unintentional newline, I assume: Two spaces between the bolded words: [Edit: well there are two spaces on the blog, but S4ME seems to remove the extra]