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Absolutely nothing, I hope, as long as America's version of Wessley is in charge of our thing over there.

I wouldn't trust the results of a neuropsychological test battery administered in such widely differing conditions. Maybe the LC group is the sickest and is lying in bed fiddling with it on a smartphone or tablet while the healthy functioning people are more likely to be sitting at a proper...

Language typically associated with anxiety disorders/phobias.

Yup, BPS 2.0, with some neurobabble thrown in about the insula.

His NIH job description says "he officially joined the NINDS Clinical Neurosciences Program as a Staff Clinician in 2021 heading the Interoceptive Disorders Unit" https://research.ninds.nih.gov/staff-directory/brian-t-walitt-md-mph

Yeah, because she had that sinking realisation of "I see where this is going".

IVIG has already been tried in ME/CFS and POTS and it didn’t work. My god, do these people even bother reading work that has been done before them.

One of the 17 participants has publicly shared her experience which sounds pretty harrowing. I hope she suffered no long term damage. It is a reply to this Bateman Horne Center Facebook post about the study...

Are the raw data available?

In my experience, it depends on the personal bias of the rheumatologist. Some will call this UCTD, others will call it "get out of my office and don't come back". I saw a few rheumatologists when I was a young woman with fatigue, sore joints, ulcerations, hair loss etc. and very high ANA titres...

The press coverage has been as dazed and confused as the paper itself which also has no clear message. Normally studies of such low quality would get no press coverage and would struggle to get published in a legitimate journal but thanks to the prestigious institutional affiliation of the...

Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome American study with a CFS group (n=60) and two controls groups. Control group 1 consisted of allergy and depression patients. Control group 2 was healthy controls and blood donors. 68% of the ME/CFS group was ANA-positive...

This review from Scheibenbogen's group says the following: 2.3.1. Autoantibodies against nuclear and membrane structures Antinuclear antibodies (ANA) were found in one study in 68 % of ME/CFS patients with the majority directed against the nuclear envelope [51]. Further studies showed ANA in...

I thought Walitt was a rheumatologist. I'm very surprised he showed no interest in this.

I can't believe Nath's media comments. Trials? On the basis of a terrible n=17 study which found no evidence of a virus or anything clearly wrong with the immune system.

The 2-day CPET literature isn’t clear-cut at all and different studies have reported different abnormalities (and lack thereof). This has been discussed at length in different threads. I do think this was a missed opportunity, as 2-day CPET findings require independent replication. Though with...

Natural History of Post-Coronavirus Disease 19 Convalescence at the National Institutes of Health The principal investigator listed on this is Walitt (scroll to the bottom). We have another paper of this sort to "look forward to".

Looks like Walitt and Nath are in charge of the Long Covid study at the NIH. At the National Institute of Neurological Disorders and Stroke (NINDS), Senior Investigator Avindra Nath, who’s known for his work on how infections affect the brain, and his colleague Brian Walitt(external link) have...

That's quite a stretch. This study doesn't prove anything. They've found basically nothing.

Data entry errors in Supplemental data file 6 which reports results of neuropsychological tests used to detect malingering. The means and standard deviations are the same for controls and ME/CFS patients for every test, down to each decimal, which is impossible.