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  1. Sid

    USA: Mount Sinai PACS clinic and Dr David Putrino

    There is literally zero evidence for this word salad. As far as I can tell based on the totality of published literature, the immune system is functioning normally in ME/CFS.
  2. Sid

    USA: Mount Sinai PACS clinic and Dr David Putrino

    So many of these LC newcomers reinventing the wheel. It’s quite annoying watching the same nonsense from 40 years ago being fed to a new cohort of people.
  3. Sid

    Cochrane: Physical interventions to interrupt or reduce the spread of respiratory viruses, 2023, Jefferson et al

    I wore N95 every time I got on public transport and at work. Never caught covid or any real cold/flu for years despite working in a hospital. Then 3 years into the pandemic the person who lives with me went to a social event unmasked, caught covid and infected me at home. Before that, I was...
  4. Sid

    Subcortical and Default Mode Network connectivity is impaired in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2023 Inderyas et al

    When I saw this bit, I knew who the author would be without even clicking on the link.
  5. Sid

    USA: Mount Sinai PACS clinic and Dr David Putrino

    More than a little premature if we consider the fact that many people develop ME/CFS without any apparent viral/infectious trigger.
  6. Sid

    The Observer/Guardian article: Does the microbiome hold the key to chronic fatigue? About patient led 'research' group Remission Biome.

    There is also a certain arrogance of people who have been sick for 5 minutes to assume that their half-baked ideas such as abx haven't been tried thousands of times before (with disastrous results).
  7. Sid

    Long Covid drug BC-007 research news

    It looks like they got rid of this:
  8. Sid

    Long Covid drug BC-007 research news

    The inclusion criteria for this study are making it very hard to recruit. Machine translation of the tweet:
  9. Sid

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    Same, except the SSRI part. I was told it was TATT - Tired All The Time - and told never to come to this office EVER again. I never mentioned the word fatigue or tiredness, by the way. My presenting complaint was tachycardia.
  10. Sid

    Post-Exertional Malaise - a discussion including defining and measuring PEM

    I think malaise describes how I feel on a daily basis very well. However, I can understand the reservations about it. It has a certain fin de siècle dramatic/hysterical ring to it, perhaps because it's a French word.
  11. Sid

    Preprint Females are less likely to receive bystander cardiopulmonary resuscitation in witnessed out-of-hospital cardiac arrest, 2023, Munot et al.

    If you are a woman, particularly reproductive aged woman, bystanders are significantly less likely to use a public defibrillator on you than on a man with cardiac arrest. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2806840
  12. Sid

    Preprint Females are less likely to receive bystander cardiopulmonary resuscitation in witnessed out-of-hospital cardiac arrest, 2023, Munot et al.

    20+ years ago an elderly woman clearing snow with a shovel (what possessed her to do this, I will never know) fell down dead beside me of cardiac arrest. It was extremely sudden with no warning, she just went blue and nonresponsive. Back in those days there were no mobile phones or...
  13. Sid

    Mitochondrial abnormalities in the postviral fatigue syndrome 1991 Behan et al

    This study was discussed years ago on the previous forum. My recollection is that none of Behan's stuff could be replicated elsewhere.
  14. Sid

    Neurometabolic Alterations in Children and Adolescents with Functional Neurological Disorder, 2023, Charney et al.

    Literally everyone on the planet has experienced one or more of these adverse events.
  15. Sid

    Neurometabolic Alterations in Children and Adolescents with Functional Neurological Disorder, 2023, Charney et al.

    I know I shouldn't be laughing because this is deadly serious for people who are told they have FND but this is actually insane and reads like a parody of some medieval text where everything is attributed to ghosts and demons.
  16. Sid

    Preprint Females are less likely to receive bystander cardiopulmonary resuscitation in witnessed out-of-hospital cardiac arrest, 2023, Munot et al.

    No surprise there. Previous research has shown that females having a heart attack are more likely than males to be diagnosed with anxiety by emergency room. The same beliefs extend to the general public as we see here.
  17. Sid

    Trial Report Naltrexone 6 mg once daily versus placebo in women with fibromyalgia: a randomised, double-blind, placebo-controlled trialBruun 2023

    Cohen's d of 0.23 is a small effect size, easily caused by functional unblinding because LDN causes obvious/known side effects. It's almost certain to fall below MCID perceptible by the patient or the clinician.
  18. Sid

    Trial Report Naltrexone 6 mg once daily versus placebo in women with fibromyalgia: a randomised, double-blind, placebo-controlled trialBruun 2023

    Komaroff's comments read like a parody. Personal clinical experience with ONE patient vs. n=100 double-blind placebo controlled trial.
  19. Sid

    Neuroimaging in Functional Neurological Disorder: State of the Field and Research Agenda, 2021, Perez, Carson, Edwards, Hallet, Stone et al

    The rebranding of hysteria to FND has been a huge success for the neurobabblers. Many patients are initially hoodwinked by the respectable sounding name. Eventually though when they get denied any further investigations or access to healthcare, they’ll learn what FND means on the streets.
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