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Looking at data from Chinese hospitals to try to make a model that predicts methylprednisolone effectiveness. Based on preliminary analysis, they selected these variables for training several types of machine learning models: They trained 6 types of machine learning models, and based on...

An Interpretable Machine Learning Model for Predicting the Effectiveness of Low-Dose Methylprednisolone in Treating Long COVID: A Retrospective Study [Line breaks added] Abstract Long COVID is a chronic, multisystem disease with limited response to conventional treatments. While low-dose...

Noting that this is a follow-up to a previous paper from the same author on the same data: Cerebrospinal fluid metabolomics, lipidomics and serine pathway dysfunction in [ME/CFS], 2025, Baraniuk

This paper says: 124 is that other paper. It does appear that the other paper has other results not included in this one, and the wording is changed throughout the paper. I haven't read either of these in detail, but just as a rough measure, there are 1782 words in this paper's Results...

They talk about results of administering a replacement for vasopressin. I made a thread for an older study of desmopressin for POTS: Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrome, 2012, Coffin et al

This is from 2012. Posting because desmopressin is a synthetic version of vasopressin, and a recent study found low vasopressin in ME/CFS: Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Endocrine Practice Edit: See also a small uncontrolled trial of desmopressin...

Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrome Background Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate on standing, and many patients...

I see there are about 22 out of the 115 genes that are primarily brain genes (high expression in brain, low expression everywhere else) based on the heatmap. None of the other tissues really stand out as having their own specific set of genes.

Hormonal alterations in adolescent chronic fatigue syndrome (2010, Acta Paediatrica) Their definition of CFS is 3 months of disabling fatigue:

Note that the case definition is only based on fatigue:

The paper refers to previous studies with similar results. Quotes from referenced papers: 15. Bakheit et al. Abnormal arginine-vasopressin secretion and water metabolism in patients with postviral fatigue syndrome. Acta Neurologica Scandinavica. 1993. [Article] [S4ME] 16. Wyller et al...

See new study with a similar finding: Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Endocrine Practice (Link to thread)

This is a 2010 study. See similar finding in a new study (note that antidiuretic hormone is a synonym for vasopressin): Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Endocrine Practice (Link to thread)

Hormonal alterations in adolescent chronic fatigue syndrome Aim The chronic fatigue syndrome is associated with alterations in the hypothalamus‐pituitary‐adrenal axis and cardiovascular autonomic nervous activity, suggesting a central dysregulation. This study explored differences among...

2017 paper. Note that antidiuretic hormone is a synonym for vasopressin. This paper was mentioned in a new study which found low vasopressin: Low Vasopressin In Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Endocrine Practice (Link to thread)

Down-regulation of renin–aldosterone and antidiuretic hormone systems in patients with myalgic encephalomyelitis/chronic fatigue syndrome Miwa, Kunihisa Background Central nervous system dysfunction associated with myalgic encephalomyelitis (ME) has been postulated as the cause of chronic...

I think that's specifically about excluding people that recently had COVID to make sure the association they're seeing is related to long COVID and not acute:

I think that's referring to this: So it's looking at pre-COVID social support's effect on the association between LC symptoms and lonelineless post-COVID. I also wouldn't necessarily expect pre-COVID advil intake to modify the association between long COVID and pain symptoms post-COVID, and...

Does this actually happen? The name ME has been around for decades, and I don't see people doing this play on words. People don't pronounce it "me", do they?

Why not if one considers loneliness a distressing long COVID-associated symptom that might be relieved by something like an online support group, in a similar way to how pain might be relieved by a painkiller?