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Exactly! Just that these people don't deterioate.

That could explain why GET doesn't harm absolutely everyone, and there are people who believe it helped them.

This is exactly how I approached retaining/rehabilitating myself when I tried the psychological approach. I became convinced my physiological symptoms were a response by my brain to 'protect' me from drinking alcohol (recovering alcoholic) by keeping me in the house. I remember jogging down the...

Also, I wonder if those planning the second round of Stimulate ICP trials are aware of this study...

Another thought - you have said that the studies you have had advance sight of will bring significant progress but there will likely be more experiments to do before we are in the home stretch. So does it follow that those studies should probably look at severe patients to get the best results...

I think the complication is that I don't know how likely those of us who deteriorated severely from intense exercise would have been to become severe without it. I had a lot of viral hits, several head injuries and countless big exertions in the three and a half years before I began pushing...

What do you make of the fact they found raised IFNy and CD38 in severe patients? As well as TNF and IL-17 which have come up on here before.

See this is totally reasonable and I can absolutely see that being the case. But I got the impression that wasn't what Cliff et al were implying.

It is interesting that they found CD38 and IFNy in severe and not in milder patients..

I find this line of inquiry extremely concerning. The idea that mild and severe are different diseases seems totally illogical to me. You would have to discount a lot of patient testimony to even consider it. Personally, I was mild for three and a half years before becoming severe. I slowly...

I hadn't heard about this! Was this Fluge and Mella too?

How great would it be if this turned out to be true/causative?

This man has entirely too much influence.

I think it could be either. Hopefully preliminary results in two years.

A huge amount of the long covid phase 2 drug trials took around 2 years.

Yes it tends to occur when my PEM is worse

Although it says 2030 completion on the clinical trial site are we really sure it's going to take that long? Seems ages for a relatively small phase 2.

Hers she says feels like she's been drugged. Like it doesn’t feel like normal falling asleep. And she sleeps for a couple of hours typically when it happens. It's been the case since I met her, 2 years before we got ME but she had had post viral illness before then after glandular fever.

I don't really know much about either

How would one test this hypothesis? Is it something that can be measured somehow or would it be a therapeutic experiment? Do you mean several different ME/CFSes or different diseases like ME/CFS, narcolepsy and cataplexy all sharing the same mechnism?