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As a kid exercise was a trigger for my migraines that could last up to three days. I have wondered sometimes if it was the first signs of my ME, but I outgrew it and headaches are not a common PEM symptom for me (I can get pulsating pain around the eyes at times I've overexerted myself, but it...

Posts about the heart failure drug vericiguat has been moved to a new thread: Vericiguat [drug for heart failure mentioned by Prof Schiebenbogen]

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I read it like Trish does, it makes sense to me from how it would be said in Norwegian.

Sure that could happen, but there are a lot of environmental factors that can influence these proteins and how they behave. Potential detriemental effects from diet, drugs, infection, bloodflow to the gut etc can be present even if the genes are fine.

The mediterranean diet is typically considered "high fibre", but there are >30 indexes to measure adherence to this diet.. For example some use a threshold value for the amount of fibre or vegetables to be included in a diet for a participant to be seen as "adhering" to the diet, others use...

But fish intake also induces TMAO, and high fish intake is generally associated with health benefits.

This sounds like my experience too.

I hope it works out for you! Little else to contribute to the thread as I don't use the pill.

It's good they write it as many are unaware of what the mice are regularly fed, which is problematic when extrapolating to what humans eat. The reason I wanted the normal chow mice data included in the other plots is because we see different prevalences of illnesses between people who move from...

While I think pwChronicIllness need more of certain compounds than others to alleviate the extra stress put on the system by illness, I find it unlikely that patients have a markedly lower isoflavone content in their diet than healthy controls. This quote from the background makes me wonder if...

I would also easily have been excluded from this data. I'm mild/moderate, and have been ill for years, there's very little the GP can do for me. The last years I have mostly gone to see one to get documentation of illness for university, which would be one visit a year. Not everyone has such a...

Zonulin and tight junctions are pretty cool, and possible to influence through environmental factors such as diet and possible sunlight exposure (high vitamin D levels in cell culture is protective against tight junction disruptors, but values used in such studies are higher than what is...

The paper says: The values most closely associated with the date of the documentation of fibromyalgia were used in this study. So it is possible, depending on how often these tests are run where the study was performed. They are using their own facility's cutoff for deficiency, which may be...

Interesting that they've used <400 ng/L as a threshold for deficiency, that is much higher than the lower reference points seen in Norway at least (I've seen the lowest points lie between 140-170 pmol/L, equivalent to 190-230 ng/L). I wonder how the results had been if these lower thresholds had...

I don't think I'd have described it as a head of a causal pathway, but otherwise yes you're on the right track.

Yes. The normal range says little about what the optimal levels for the individual is, and some might be deficient even if they are within the "normal" range. It's so frustrating that even with symptoms of deficiency a lab test within normal (it can even be just within the range!) and everything...

I wish we could be sure things like this were ruled out early as part of a screening, sadly that's not always the case :( Not saying it's the case with you @Daisybell, just a general observation and frustration. :)

Now that you mention it there was an opinion piece from a GP here in Norway recently about how in some litterature relevant for medical professionals diabetes types II is still called "old man's diabetes" while type I is referred to as what occurs in children. This causes problems when people...

I've also seen it the other way around. I don't think I know about any other disease with this type of naming issues..