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I was looking for something else and came across this. I've only read the abstract, but will look at it more later as two different states of flux through beta-oxidation seems interesting, especially in light of other hypotheses on metabolic traps the body can get stuck in. Obviously from a...

Abstract In this study we demonstrated through analytic considerations and numerical studies that the mitochondrial fatty-acid β-oxidation can exhibit bistable-hysteresis behavior. In an experimentally validated computational model we identified a specific region in the parameter space in which...

But it has to be done at the correct time. The example used in my system's modelling class was medium chain fatty acid dehydrogenase deficiency, where the patients had to be fasting for the peculiarities to show up in the blood. If the patients had presented well fed the concentration of the...