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Something like heat shock proteins being dysregulated might explain the poor stress and exertion tolerance of patients (they don't just protect cells against heat shock but against many types of stressors).

Not liking the positive spin in the abstract. The questionnaire results don't look impressive and are uninterpretable due to lack of controls. I suppose the purpose of the study is to show LDN isn't causing any obvious serious harm so that a proper clinical trial becomes easier to get funding for.

Illness doesn't begin at diagnosis. It's likely that all these people are already sick with whatever illness they have, even if it takes another few years before they're diagnosed. In that time, the illness could destroy their life and cause "life events". By the time people make contact with...

HSF2 is required to maintain cell-cell adhesion HSF2 deficiency leads to downregulation of cadherin superfamily genes Impaired cell-cell adhesion sensitizes cells to prolonged proteotoxic stress Cadherin-mediated cell-cell adhesion is a survival determinant upon proteotoxicity...

Blog by a person who tracks her health data over time. Observations Summary: Fluctuations in temperature, resting heart rate, inverted HRV, and activity levels are all tightly correlated & periodic with my menstrual cycle. Counterintuitively, I seem to have more energy when resting HR is...

Hanson et al did not report which type of cadherin was elevated in ME/CFS, if any. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7931008/ If one type of cadherin stood out from the others, it would hint which type of tissue was involved. VE-cadherin would suggest a vascular problem and whatever...

Adhesion molecules are cell surface proteins that mediate the interaction between cells, or between cells and the extracellular matrix (ECM). There are four families of adhesion molecules: immunoglobulin-like adhesion molecules, integrins, cadherins and selectins. ME/CFS was associated with...

Something that has also happened to me is eating a lighter dinner than usual, and the next morning going out for a walk after the usual breakfeast and ending up having what felt like a mild episode of hypoglycemia.

When reading papers like this, I always have to think back to when I was getting therapy for "school refusal" (actually crippling fatigue, but that wasn't allowed to be real, it had to be a psychological problem) and I treated therapy as some sort of process where I had to go along with whatever...

A bit more information on what the WAVE3 gene does in the cell besides having something to do with mitochondria. It's part of a protein family that is also involved in cell movement, which involves restructuring of the cytoskeleton. I'm not entirely sure but believe that cell adhesion and...

Increased expression of this protein seems hard to interpret because it's involved in so many different things. But that the NIH is doing a mitochondrial study led by a cancer researcher suggests that they might be thinking that the interaction between WAVE3 and mitochondria is the most...

My understanding is that the link to mitochondria is autophagy (degradation of damaged cellular components) and maybe also organization of the mitochondrial network. It also has various other roles. But this is a complicated topic and I may be misunderstanding. I'll have to read more. It's...

Processes this gene is involved in involved_in actin cytoskeleton organization IBA PubMed involved_in actin filament polymerization TAS PubMed involved_in cytoskeleton organization IMP PubMed involved_in lamellipodium assembly IEA involved_in modification of postsynaptic actin cytoskeleton...

The pre-publication thread has been merged with the thread on the paper. Link to paper's abstract here...

I also doubt that PEM defined as pattern of symptoms worsening with a delay after exertion is unique. But it could be a situation where there are different kinds of PEM that are not being distinguished due to lack of research. What is seen in the 2-day CPET may be much more specific, and there...

I had a pulse pressure of 20 at times. I interpreted it as likely being due to low blood volume (mimicking the effects of major blood loss). It varied a lot over time so seems to make heart disease as cause of it unlikely. Faulty regulation of blood volume and water content of the body seemed to...

I should mention that I can have PEM before sleeping too, but my typical presentation is next day PEM after sleep. I don't know enough about the topic to make specific predictions, if that's even possible at the level of knowledge we have. I also remembered that there was this recent paper...

It's difficult to know what really happened. It's possible to emphasize different symptoms and aspects in the same disease. That Ramsay emphasized these doesn't mean the patients didn't have the symptoms that are emphasized today. Maybe at the time physicians were trained to describe disease in...

I took manganese for a while after finding out I may be deficient as it seemed like potential cause for some of my symptoms. My impression is that it didn't do anything. That doesn't mean there's no merit to the idea. If there is a deficit, it might require a different approach or dosing or...

This idea has come up before and I thought it would be interesting to write down some of my thoughts on this. Housekeeing processes have a role in keeping cells healthy by doing things such as maintaining structural integrity and degrading and recycling intracellular components (like...