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I know of this study which shows that neuropathic pain improves with TCAs but not SSRIs. I suspect this is significant as to pharmacological treatment of ME/CFS symptoms.

Hi @Hip, When I was asking about IgG in another thread, @Aroa foind this for me in Naviaux’s work (https://www.omf.ngo/2016/09/09/upda...-fatigue-syndrome-q-a-with-robert-naviaux-md/, question 11): I’m interested in IgG because my daughter’s tetanus toxoid IgG increases with histamine...

Thank you so much for starting this thread.

And this treasure: http://www.simonwessely.com/Downloads/Publications/CFS/179.pdf The act of diagnosis: pros and cons of labelling chronic fatigue syndrome MARCUS J. H. HUIBERS AND SIMON WESSELY Psychological Medicine, Page 1 of 8. (c) 2006 Cambridge University Press...

They used CDC and NICE (ie. “adolescents reported by their mothers to have experienced fatigue lasting >6 months that was associated with absence from full-time school or that had prevented them from taking part in activities ‘quite a lot’ or ‘a great deal’.“) and speculated that the obesity was...

some PwME seem to struggle with obesity, whereas others can’t seem to maintain a healthy weight and are clinically underweight. I wonder what the factors are that might lead to that?

My understanding is that body temperature is set by the hypothalamus in response to various triggers, including immune response.

Here is the full paper: https://dacemirror.sci-hub.tw/journal-article/ebbbfdfc7a38c456b049f8639bbbdc05/engelmann2004.pdf It describes an experiment where rats were subjected to a psychological stressor (social defeat) and a physiological stressor (drowning) and compared their PVN response. The...

This is my theory of ME/CFS. The PVN is involved in physiological stress responses, as evidenced in this old study: The hypothalamic–neurohypophysial system regulates the hypothalamic–pituitary–adrenal axis under stress: An old concept revisited Mario Engelmanna, Rainer Landgrafb, Carsten T...

Moderator note: This post and discussion has been moved from this thread: A compromised paraventricular nucleus within a dysfunctional hypothalamus: A novel neuroinflammatory paradigm for ME/CFS, 2018, Mackay, Tate. This is my theory of ME/CFS. The PVN is involved in physiological stress...

My first issue with this study is that the secondary aim: is predicated on the expectation that health anxiety will be found in the CFS sample. This shows the researchers are biased.

Thanks @JemPD, she is 12 now and has almost completely recovered/remission with low-dose cortisone.

I think it means making people believe fairy tales doesn’t make them better...

I just don’t know which part of my daughter’s personality is related to ME and which part is related to her being a Virgo. It is so confusing. Especially because she was only 5, and was always very neat with the crayons.

Hypothalamus = brain = BPS to a psychiatrist I think that is the bottom line. But I just don’t think there is any evidence that conscious thought can influence chemical processes, anywhere in the body. Is there?

Isn’t a “nonrandomised uncontrolled trial” kind of like asking my husband if my bum looks big in these jeans?

:hug:

I think perseveration would be diagnosed as such: “Every time I eat <insert activity>, my <symptom/s> start...” “Now that is not possible, let’s talk about your distant/non-existent/forgotten childhood trauma...” “No, my <symptom/s> start when I <insert activity>”. Done.

Those oaths are highly distressing. I have seen the worst in humanity in doctors.

I am so pleased to read your post @Jonathan Edwards. It makes no sense to me. And yet every slightly-less-scientific page I read (web, print, whatever) on inflammation notes that decreasing “stress” (emotional) helps reduce inflammation. I wondered for a long time if I was just not reading the...