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Hello everybody. I am recruiting for a couple of studies but chiefly doing this via one study recently funded by ME Research UK (grant held by Dr. Sarah Annesley). Looking for females only, residing in VIC, Australia only due to short sample lifespan (part of this work is various experiments...

I do not think that current evidence indicates mitochondrial genome issues. The best targets relating to mitochondria that we have are probably FBXL4 and WASF3. Both are nuclear-encoded. I haven't read this paper yet, just making the comment as it is the first thing that comes to mind on this...

Nothing is ever dead unless directly proven to be so and many would posit, philosophically, that we cannot prove the absence of something. What we can can say is that attempts to demonstrate the presence of the thing continue to fail. That does not indicate that it is fertile ground for...

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another nail in the coffin i guess.

Every cent will go directly to ME/CFS research as I understand it, split evenly between two laboratories at LTU both working on ME/CFS projects. I have worked in both laboratories and currently work within one while collaborating with the other.

ChatGPT “give me a title for this” maybe?

Everyone who is actively dedicating their time to shared knowledge in good faith. So all of you, to start with. Sometimes things are gotten wrong or get lost in the weeds, but the scrutiny and collaboration here on s4me is an accelerant in homing in on ideas most likely to be productive. I...

Not replicated in similar study with more modern well content normalisation strategy https://www.s4me.info/threads/using-the-thermal-power-of-light-to-affect-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-2025-hochecker.46807/ Opposite direction seen, likely due to differences in...

Woo thermal whatever aside, more seahorse done on mixed PBMC which is impossible to interpret due to differences in oxidative metabolism between different subpopulations. It does serve some purpose. In directly contradicting the 2017 Tomas paper (more basal respiration, not less) it seems to...

In as many uncountable ways as any number of metabolic disturbances if present may interact with processes that we believe may drive the illness. These particular pathways affect pretty much all of the cell. It has to be framed within a specific, start-to-finish signalling process to be...

rapamycin is a f***ing nasty drug so seeing anecdotes of people losing baseline and reading here that drop-outs were excluded from the results is worrisome given that people are going to see this study on twitter and ask their doctor for a prescription Need double blinded rct urgently to clear...

I have nowhere close to enough time to look yet... is this mitochondrially encoded genes or mitochondrially localised gene products? Or just with some association with mitochondrially relevant pathways?

Relevant to discussions raised in DecodeME thread https://www.s4me.info/threads/initial-findings-from-the-decodeme-genome-wide-association-study-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-2025-decodeme-collaboration.45490/post-646493

One thing is that if we take immune cells and then the pathway hits are broadly immune related that isn’t really saying much, since it’s what would be expected by chance.

I should have mentioned that this was my reasoning!

In terms of specific functional implications I’m not sure what we can draw from this study because it is mixed PBMC

Is this the case? I don't have time to dig thru the paper

Are there any ML multibiomarker thingys actually used to diagnose any illnesses? I haven't encountered it

I was yesterday reading a recent nature paper about mechanisms by which this may occur as tested in mice: https://www.nature.com/articles/s41586-024-07469-y The abstract etc are full of buzzwords but the actual experiments seem interesting.