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The best web resource I've found is https://www.mastattack.org/2014/10/mcas-treatment/ I've pointed to the treatment page but the rest of the site has some well written material also. One doctor who seems to treat it a fair bit has some blogs that also describe drugs and dosing...

Moved posts from Diagnosis of mast cell activation syndrome: a global “consensus-2”, 2020, Afrin et al Warning: anecdotal I've been mostly bed bound for the last couple of years. Enough energy to do daily tasks and even small workouts, but the PEM has ruled. A couple of weeks ago I had a...

When I'm lying down I compose email responses in my head, often recomposing them until I get them right. As soon as I stand up and walk into the computer room the thoughts are gone. For years I would sit at the computer first and wonder why I had writers block.

"Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not eliminate latent HSV, and thus is only suppressive rather...

Abstract The outbreak of SARS-CoV-2 infection has enormously impacted our lives. Clinical evidence has implicated the emergence of cytokine release syndrome as the prominent cause of mortality in COVID-19 patients. In this study, we observed massive elevation of plasma Galectin-9 (Gal-9) in...

Abstract Numerous mitochondrial constituents and metabolic products can function as damage-associated molecular patterns (DAMPs) and promote inflammation when released into the cytosol or extracellular milieu. Several safeguards are normally in place to prevent mitochondria from eliciting...

"Successful elimination of bacteria in phagocytes occurs in the phago-lysosomal system, but also depends on mitochondrial pathways. Yet, how these two organelle systems communicate is largely unknown. Here we identify the lysosomal biogenesis factor transcription factor EB (TFEB) as regulator...

"This review provides a brief history of how our knowledge of endothelial function has advanced and now recognize that the endothelium produces a plethora of signaling molecules possessing paracrine, autocrine, and, arguably, systemic hormone functions. In addition, the endothelium is a...

"The findings of the present investigation provide evidence that aging-related endothelial dysfunction and arterial stiffening are significantly ameliorated in a mouse model of aging upon treatment with SGLT2 inhibition. Specifically, a 6-week treatment with Empa resulted in greater eNOS...

Here is the actual paper https://pubs.rsna.org/doi/10.1148/radiol.220492

MRI technology finds problems with gas exchange in long COVID https://pubs.rsna.org/doi/10.1148/radiol.221098 The news article is a bit easier to read https://globalnews.ca/news/8950820/long-covid-canadian-researchers-causes-study/ "All 34 of the patients who participated in the study were...

Here is another talk, this time to a group of Australian doctors. It is a good and recent summary of his research, including insight into why they are following their current path. As an aside (beware "works for me") After I'd been taking pravastatin for a month or so, about an hour after...

Here is a talk Patterson gave at a recent research symposium https://www.mybeckman.ca/resources/videos/symposiums/covid-symposium-day-3-session-3-bruce-patterson

THC 32mg/g CBD 0.0 The 30ml bottles come with a syringe that stops a standard dose at .3ml, which is about 3 drops. I've never used more than one standard dose. The CBD bottles are CBD 100mg/g THC < 3mg/g I also use the CBD occasionally on days where I might have to drive. I find even with a...

Here goes anecdotal evidence. I've been using pravastatin for about two months. It took about a month before there was a noticeable effect. As a geek, one of my metrics is how much a feel like programming. Suddenly I went from no interest in programming for many months to spending an hour or...

I often have the same feeling, which I describe as despair. It can be over something as small as dropping a pencil on the floor. That is my signal to go have a nap. In the same way, even a short nap makes the feeling go away. The precursor seems to be an irritability about everything. Now my...

If you already happen to be taking a statin, switching to pravastatin would seem to be an easy test. The study uses the common standard dosage. I'm already taking a statin. In a routine follow-up I explained my rationale to my doctor from a lipid clinic. He had no trouble making the switch. As...

"Reneo is a clinical stage pharmaceutical company focused on the development and commercialization of therapies for patients with rare genetic mitochondrial diseases, which are often associated with the inability of mitochondria to produce adenosine triphosphate (ATP). Reneo is developing REN001...

maraviroc is used as an HIV drug. In order to ensure its efficacy they run a tropism test. It may be that in some people the CCR5 mechanism may not work and a CXCR4 mechanism may come into play. https://www.catie.ca/maraviroc-celsentri pravastatin sometimes seems to be implicated fatigue and...

Many years ago I had an allergic reaction to a wasp sting that resulted in a trip to the emergency room. It was severe enough that I had hives all the way down my back. I was given IV antihistamines and adrenaline. When I left the ER I walked home for 40 minutes. The next day or so was the best...