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Just leaving this here: https://www.theguardian.com/education/2003/dec/09/highereducation.uk2

Soooo.... just to play a little bit of devil's advocate, I welcome the study. Yes, there are some issues regarding criteria for judging symptoms and the history of the group involved - but hearing/seeing the Today Programme and the Guardian write something about ME/CFS that implies a cause...

Cross-linking to @MeSci's post on Carmine Pariente's latest paper 'Persistent fatigue induced by interferon-alpha: A novel, inflammation-based, proxy model of Chronic Fatigue Syndrome', which notes: This would seem to tie in with the prediction made by @RDP as shown on the slide on the very...

Hi @Woolie, I came across this thread whilst looking for forum posts on Ranitidine. If you don't mind me asking, how are you finding Cimetidine six months on? Were the initial positive signs sustained?

Even then, it's hard to argue that NKC function would be a valid biomarker for ME/CFS given reduced NK cell function is also seen in depression: Reduced natural killer cell cytotoxicity in depression but not in schizophrenia Reduced natural killer cell activity in major depression...

And we're glad you did - excellent summary. 2-day CPET (with 48 hours inbetween) seems to be the best biomarker for now - but they've always been small studies and have seemingly struggled to get traction. Does anybody know if there's anybody trying to replicate on larger numbers and (just...

Recognising that knowledge is a spectrum (e.g. despite a lot more funding, we know surprisingly little about ASD, IMHO) and so it's not a binary case of either knowing a lot or not, I would say the biggest gaps are: reliable, consistent, objective biomarkers pathological mechanism(s) <--- this...

Good point, I had assumed it was from that study due to the number of participants, but that's quite possibly wrong.

I was mulling this over and I think *theoretically* you could get the p values mentioned with an N=18 sample. I agree with the above that sampling hundreds of cells gives you more confidence of the deformability value for a given patient/control but does not provide greater confidence of the...

I'll be interested to read the full paper when it's available (or perhaps if it's available - if this is an abstract of what will be presented at their conference then this may be all that is published for now). For now - like so much recent ME/CFS research - it's in the...

To add: the study also cites this paper (that I hadn't seen before) that has the frankly astonishing fact: If almost a third of multiple sclerosis patients are initially misdiagnosed with ME/CFS or general fatigue that raises an even bigger ethical issue with MUS practitioners' recommendation...

New Scientist has a good overview here: https://www.newscientist.com/article/2186387-ms-symptoms-improved-by-treatment-that-attacks-glandular-fever-virus Some bits I found interesting: This seemed redolent of the VanElzakker hypothesis regarding the vagus nerve. For progressive MS...

Can an inferior version of Marmite really be considered a unique contribution? ;-)

Thanks all. Lots of helpful replies and, as suspected, heterogeneity in experience (like absolutely everything else with ME/CFS...) From what I know of the 'fever effect', it's relatively controversial: as it is based on the behavioural reports of parents with children with severe autism, it...

Two weeks ago I spent a week in the US at a work conference (Recap: I have generally a mild, though there have been prolonged times housebound and at certain times close to fully bedbound - I am still in full-time work albeit about 60% from home). This is always tricky for me as it involves a...

I've just read Cort's overview of the hypothesis (I'm still to watch the OMF videos - are they broken down on YouTube yet?) and other than giving me a shudder of horror, recalling systems engineering lectures from almost two decades back, my main question is this: wouldn't an inhibition in...

I massively agree - the point here is not around whether ME/CFS is a physical or mental condition (and if, as I think most likely, it turns out to be neuroimmune, which of those categories would you use?). It's that even if ME/CFS were shown to be a mental illness, GET still wouldn't be an...

FWIW, I would be cautious about thinking this will lead to a specific biomarker. As Milo notes, a biomarker would need to discriminate between this and other diseases - and I believe there is some evidence that some depressive disorders noticeably impact lactate levels in the brain. Indeed...

There was quite a long delay in follow-up as they'd filled the quota but then apparently got extra funding to do more scans, which is when I was contacted. FWIW, I wasn't turned down due to any kind of ME/CFS selection criteria - the scanner they're using is much stronger than a normal MRI and...

Worth noting that a team at Oxford are also looking at lactate levels (https://www.s4me.info/threads/oxford-uk-recruiting-a-study-looking-into-energy-status-mrs-in-cfs.2661/page-2) using similar MRS techniques I believe... though when I spoke to them as a potential candidate (turned down...