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You might want to look at my Qeis article. For me ME is a defunct concept that was always too muddled to be useful. Basically a confusion of two quite different concepts. Sadly, much of the literature criticising the BPS model is as muddled as the BPS people are, and only serves to perpetuate...

You are not being dim. I think you have hit the nail on the head. I don't see the validity of the exhaustion idea as an immunologist. Edit: andI are with SL that any skewing is very likely to be due to shift in traffic and lifespan. The key problem with studies like this is that circulating...

I think the Hng piece is fairly realistic. The great majority of physicians I know do not really have ME/CFS on their radar. Nearly all have never heard of the PACE trial. For older physicians I am not sure that asking if they believe anything about ME/CFS in a questionnaire is likely to...

I understand that it can be over interpreted but I was using it in a combined argument with the fact that first day CPET in ME/CFS tends to be unremarkable. The fact that the twitch data are similarly normal in other conditions is important, I agree. But a first day CPET would presumably be...

I agree too but note that the biggest problem has been just this focus on function justifying GET as an answer to ME/CFS to increase function while totally ignoring the fact that function is driven by symptoms and that if you increase muscle function (which one exercise trial does show...

No I probably misread that but they do reference that garbage review on 'EDS' and chronic pain. And they seem to accept that EDS has 'similar common symptoms and Muti-systemic presentations'.

'Long infection' is something we have been well aware of for at least fifty years. But it is a very organism specific thing. Nor virus persists, EBV persists, Varicella-zoster persists, but most viruses do not as far as we know. If long infection is relevant to Long Covid it probably means that...

I didn't see any reference to EDS there.

This all gets quite metaphysical and when I said thing I was being general. BUT is you want to be purist and metaphysical then the modern scientific view would be that there are no things other than processes or the dispositions or powers that can entail such processes. That may seem a bit too...

That list is simply a string of un-evidenced or meaningless statements presented as expert advice. The paper is presumably just a bid to justify a profitable practice by people with nothing to offer.

ROS generation in infection is local and as far as I know not a major feature of viral infection. As an immunologist this quotes all sound to me like stringing together various popular memes without any real understanding of inflammation. And presumably if people had mutations in gremlin...

Since when was EDS a functional somatic symptom disorder? This seems to be some sort of professional consensus, while being medically illiterate. The mind/brain boggles.

The only possible reason for this group of people co-authoring a paper is to further a political objective. Unlike a proper review this is written by a collection of people whose only link is a preconceived idea that rehabilitative therapy works.

Maybe it has not occurred to Caroline and others at the MEA that a very large number of sensible physicians are likely to agree that the patients' petition is entirely justified. Maybe the ME has never realised that the organisation itself is probably regarded by the medical profession much in...

All sorts of mechanisms may well have gone under our radar. The mechanism I based treating RA on had gone under the radar of immunologists for decades despite being fairly easy to see if one thought clearly (which one can do with hindsight). Prions were totally unexpected. Even germs were...

There seems to be a deep lack of common sense in psychological theorisation that pops up in all these ideas. We are told that a pathological state is explained by some normal regulatory process - like Pavlovian conditioning or predictive coding. Yet these processes lead to normality. So there...

Yes, I agree that researchers seem not to be even trying to model that long term aspect. Theories about mitochondrial function or low blood volume or whatever never seem to provide any explanation for the long term time profile. What is not clear to me is that we know that it is the PEM...

And judging by reading a bit more of the thread the thresholds seem pretty much all over the place both for different people and individuals across time so as a scientists I wouldn't;t even try to model that.

Yes I get all this stuff but I am trying to make the point that I think in unravelling the problem scientifically the biggest mistake is to disregard the actual symptoms and focus on thresholds. Understanding thresholds needs a quantitative model and we rarely ever get that good with our...

I don't see any particular reason why. I am finding it hard to see how this concept of proteolethargy relates to disease if it occurs in both diabetes and inflammation, which present with unrelated symptoms. Much of the time diabetics with functional insulin lack are asymptomatic until...