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Yea nah I misunderstood. Inhibiting tlr4 means just that, if LDN works by this, then that's what it's doing something is activating TLR4, damps or pamps

I read that corticosteroids can increase microglia activation. As always I'm thinking on a completely lower level haha. Thank you for explaining again I suppose then you're not a fan of the neuroinflammation camp? What if they are doing what they said but forgot to turn down or something...

Sorry I didn't mean direct administration into the brain but intrathecally

LDN Tlr4 inhibition explanation If LDN works via inhibit glia tlr4, does that mean tlr4 is being activated in the first place? So what was activating? Or can inhibiting tlr4 inhibit the common pathways of other signals? For example il1. Tldr, if glia is activated by il1, can inhibit tlr4...

Wait sorry I mean if it's glia, are glia the immune system in the brain? Are we talking about glia or the main immune system?

Dude might be dodgy but his idea, is not so bad? Is mentioned similar in other places. Is it a good idea??? Good idea bad person.? From my layman's perspective, it seems he's guilty of the same things drug companies do, off label marketing?? A marketing problem. I'm glad somebody looked into...

Since they don't cross the brain bb why aren't we simply administering them centrally?

I see. Fibro = Cs, cs= glia, LDN = glia, fibro =LDN=glia. Why have I not been told this before. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6051899/ Cited 600 times. Mainstream paper that briefly touched on fibro

Paki paki matua. There's a website called British society for immunology with byte sized immunology, also rather nice. https://www.immunology.org/public-information/bitesized-immunology On that note I realise my pem isn't energy based in the same way cfs is... Whitney Dafoe can barely walk, or...

Professor, a few more. SFN neuropathy produces different signs and symptoms to fibromyalgia, what would this difference be? What were these other attempts to transfer disease with antibodies? I would like to read them 'Most autoantibodies are non-inflammatory' is this true? Because after...

https://www.bmj.com/content/375/bmj-2021-067883 somebody took this very seriously Shak I got an email for your reply but you seem to have disappeared completely. Unfortunately videos pem me too fast now, I can only read Gee. Is there any autoimmune illness where the pathophysiology is simple...

Thank for explaining. Yea... I was hoping to get answers without needing to do a degrees worth of study. I don't understand your explanation but thank you for pointing me so I know what to read. Before this I assumed antibodies just bound to the cell, then called on their friends to come take...

1 answer to 1 q I found : motor neurones sit in cns but project into PNS, but are also in the drg. But I think they still have receptors then for nociceptive stuff? I'm not sure. I was thinking if they could cause muscle twitches and tremors and I think they could, even if there wasn't...

Professor, after some thinking and more reading I realise I failed to even grasp the basic underlying concepts. Why are most autoantibodies non inflammatory? I thought they induce an immune response. What is the definition of inflammatory? Inflammatory as in induce immune response? From my...

Perhaps this is another mechanism for LDN? I don't understand. Younger mentioned nadph oxidase, astrocytes, opiod growth factor, and the rebound endorphin. But no mention of this neutrophil paper

So if you're sincere enough with bad science, you can get away... With nothing but oh well we made an oopsie. Hmm. 1 final final thing, if Goebel is right, does that mean fibromyalgia can be diagnosed in an autopsy via staining of the DRG. That would seem to be a quick way to see if he is...

Hehehe this is why I didnt listen to any dosing strategies, though I would think just logically go low go slow is a good bet for ppl w who r sensitive

Hmmm. My abdominal pain is non GI though. Interesting note though.

Don't you get fired if your hot papers are garbage though, unless nobody is ever bothered to replicate your work. Also I note you haven't read the autoimmunity reviews paper have you, cause I said he showed that 4 conditions had these autoantibodies, I was wrong. It wasn't actually he himself. I...

You and I may be in the same boat then eh... I don't know what my pain is, its not achey, and it jumps around. It's not quite what I imagine nerve pain to be, but it's certainly not physical pain. I've never experienced anything like it. Ain't nociplastic either. Now about Risperdel, you're...