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The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of magnitude affinity preference, but the physiological significance of this competition remains elusive. In mice consuming a Western diet, genetic...

I have suffered something like ME for 40 years now. For most of that time, my symptoms were mild-to-moderate and I continued with a lot of gym training and outdoor sports. (I'm currently somewhat severe and can barely function.) My body's response to exertion has always been wildly erratic, and...

I don't think Creekside is suggesting that ME/CFS should *remain* a black box; rather, by *intervening* in a select aspect of the system, whether that is Whole Body, or immune cells, or mitochondria in muscle cells, etc., by varying inputs (e.g., adding a signaling chemical, adding stress...

This doesn't get us any closer to a solution, but recognizing that it's a *control system* problem is putting us on the right *path* to a solution, I think. I was under the impression, several years ago, that Nancy Klimas' group understood that and was using network analysis to craft a...

LOL