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  1. shak8

    BMJ: Why scientists are rethinking the immune effects of SARS-CoV-2

    "SARS-CoV-2 is linked to “an unusually high level of ‘indiscriminate’ killing of T cells,”6 says Leitner, adding that this observation is “reminiscent of” measles, which can cause immune amnesia by depleting memory B cells (a different type of immune cell), leaving people vulnerable to pathogens...
  2. shak8

    Tonix Pharmaceuticals Announces FDA Approval of Tonmya™ (cyclobenzaprine HCl sublingual tablets) for the Treatment of Fibromyalgia

    Published trial results from 2023: https://acrjournals.onlinelibrary.wiley.com/doi/10.1002/acr.25142 2025 published trial results (PDF available): https://academic.oup.com/painmedicine/advance-article/doi/10.1093/pm/pnaf089/8193722
  3. shak8

    Tonix Pharmaceuticals Announces FDA Approval of Tonmya™ (cyclobenzaprine HCl sublingual tablets) for the Treatment of Fibromyalgia

    https://clinicaltrials.gov/study/NCT02589275?cond=Fibromyalgia&term=Fibromyalgia%20Syndrome&intr=cyclobenzaprine%20hydrochloride&rank=3&tab=table I'm not sure how to evaluate the current trial since it is open label, fewer research subjects than ones in two previous trials (which were...
  4. shak8

    Tonix Pharmaceuticals Announces FDA Approval of Tonmya™ (cyclobenzaprine HCl sublingual tablets) for the Treatment of Fibromyalgia

    Tonix investor conference call audio (recorded from today's broadcast about Tonmya): https://edge.media-server.com/mmc/p/gsey5g7m I'll check with clinical trials.gov and see if any publication of trial details exists. It's a sleep architecture agent by increasing Stage 4 or deep sleep, where...
  5. shak8

    Review Effect of nonpharmacologic therapies on depressive symptoms in patients with chronic fatigue syndrome: a network meta-analysis, 2025, Jiang et al

    The usual suspects in PR for traditional Chinese medicine, but guess what, a little chicken soup works best.
  6. shak8

    News from the USA, United States of America

    This is why I applied to my state's vocational rehab program before applying for social security disability: to try to find something I could do. I found a counselor there who used to work for social security disability and he showed me how to word my application for disability. That is what I...
  7. shak8

    Trial Report The Psychological Benefits of Forest Bathing in Individuals with Fibromyalgia and CFS/ME: A Pilot Study, 2023, Serrat et al

    Send Americans with FM to Costa Rica. (I've never been there.) Nicoya Peninsula is a blue zone. Slow forest bathing with sloth sightings promised, maybe tree climbing involved if sloths permit closer contact. Just to say that flying at altitude in a plane--it's freezing cold. Opioids needed...
  8. shak8

    Trial Report The Psychological Benefits of Forest Bathing in Individuals with Fibromyalgia and CFS/ME: A Pilot Study, 2023, Serrat et al

    Oh dear. If I had to go to my park with a group, plus an instructor telling us all to listen and open our minds and assorted milque-toast mindlessness dogma, well actually I have done this. I went to a forest bathing session eons ago. It was irritating in that I wanted the intructor to be...
  9. shak8

    Upper Airway Resistance Syndrome (UARS): a common underlying cause for all "chronic complex illnesses"? (ME/CFS, fibro, GWI, etc.)

    Of course, I am interested in any promising FM therapy after 30 years of the condition. But there has to be a study performed to convince other scientists or doctors that the intervention warrants further study; professionals in related fields have to get fired up about it. However, here there...
  10. shak8

    Life has less meaning without work, but most work would make me sick

    Just wanted to tell you @Hoopoe that I found the work world a pain in the b***. Expanding your self-concept toward a career-type of activity is something you may have missed out on in your teens and twenties. I don't think recapturing lost years is possible, but fashioning some sort of...
  11. shak8

    Upper Airway Resistance Syndrome (UARS): a common underlying cause for all "chronic complex illnesses"? (ME/CFS, fibro, GWI, etc.)

    I found a meta-analysis on Pub-Med by searching for sleep apnea and fibromyalgia. Fibromyalgia in obstructive sleep apnea-hypopnea syndrome: a systematic review and meta-analysis https://pubmed.ncbi.nlm.nih.gov/38831795/ Results: Fourteen studies met the inclusion criteria. This study...
  12. shak8

    Upper Airway Resistance Syndrome (UARS): a common underlying cause for all "chronic complex illnesses"? (ME/CFS, fibro, GWI, etc.)

    Sited in the post 7/20/25 @nataliezzz is Sleep-disordered breathing among women with fibromyalgia syndrome (Journal of Clinical Rheumatology, 2006) https://journals.lww.com/jclinrheum/abstract/2006/12000/sleep_disordered_breathing_among_women_with.4.aspx Full-text is pay-walled. Results...
  13. shak8

    Article: Chronic pain sufferers find relief through UK-first (virtual reality)treatment

    I, too, got excited when I read the title---at last--a promise of pain relief. I guess if one can't move and are stuck to the bed or couch and in severe pain, the VR is a good thing. I know it's been studied and used for PTSD veterans to relive their traumas over and over until the stimuli...
  14. shak8

    Life has less meaning without work, but most work would make me sick

    In the US, a high school diploma is essential for a lot of jobs. I went to college early and skipped two years of high school, but I found I needed the diploma and I took an exam for it. Just like getting your driver's license, do you think catching up with life by getting the diploma somehow...
  15. shak8

    Life has less meaning without work, but most work would make me sick

    In the US, we have certified in-person translators for the court system and on-call medical translators but probably that's via phone access, so no need to be in-person. I don't know how much education one needs, you'd have to check. Could you see what your local/regional government offers for...
  16. shak8

    Is there a psychological vaccine against untruths?

    Well, don't expect a vaccine to come out of the USA---any vaccine.
  17. shak8

    Heightened protective decision-making related to physical, but not cognitive, effort in individuals with fibromyalgia, 2025, Herman et al

    Uh-hem. If I don't have the protective mechanism software running in my head all the time, I am likely to, for instance, vacuum the whole apartment and have my usual sites of upper back pain rise from 5/10 to 7/10 for TWO WEEKS which brings a cascade of other anti-pain measures I have to...
  18. shak8

    PEM discussion thread - post-exertional malaise

    According to the Bateman Center's new clinician manual for ME/CFS, etc., the cortisol in ME is low or lacks the diurnal variation curve. See page 9 here...
  19. shak8

    Chronicity rhetoric in health and welfare systems inhibits patient recovery: a qualitative, ethnographic study of fibromyalgia care, 2025, Cupit et al

    Another false statement in this "research" paper (First being that FM is hard to diagnose): That recovery and improvement from FM are possible. Recovery, no. It is lifelong (chronic). That has been established fact by rheumatologists thousands (5000 for Dr. Robert Bennett of Oregon Health...
  20. shak8

    Upper Airway Resistance Syndrome (UARS): a common underlying cause for all "chronic complex illnesses"? (ME/CFS, fibro, GWI, etc.)

    Upper airway resistance as the cause of damn near everything is a "homeopathic hypothesis" in that the effects of miniscule airway resistance measurements do not, and cannot account for clinically relevant underpinnings for FM, ME, etc. That being said, I posted the emboldened phrase to the...
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