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I’m trying to look for a possible lead: I recently had high blood-measurements of Circulating Immune Complexes (CIC) at 2 different time points Early September : 130 (reference range 0-20) Half October : 78 (range 0-20) October was AFTER a immune suppressive treatment Note: Circulating...

This wearable lactate monitor will be launched in 2026 - monitor working on the same principle as the glucose meter under skin / same principle as the glucose meter in skin - linked to a smartwatch, as far as I understand PKvitality’s SkinTaste® micro-sensor technology, K’Track Athlete is the...

“Lactic acid” and “lactate” are often used interchangeably, but physiologically they are not the same. You can only measure lactate in blood as far as I know, so that’s the data where we have to go from. Apart from the publication, I posted, I know quite a few patients that tested high for...

I’m not so bothered about the anaerobic threshold. I’m interested in the correlation MECFS / PEM and lactate levels. From that n=123 paper : 45% patients had lactate values around 2 mmol (or sometimes higher) at complete rest: - “ resting conditions in hospital bed for at least 30  minutes and...

With regards to evidence for lactate in ME CFS or with PEM - there are 2 Research publications 1) Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with ME CFS From abstract : The study included 123 patients. - Elevated (n = 55; 44.7%) and...

Would it make a difference for you if it said : exerting above a certain threshold causes PEM ? Yes, brain fog / neural symptoms is (probably) not explained by exercising beyond an anaerobic threshold - although I’ve read a study about lactate levels in the brain. (I will post this one in...

Yes. 100% My conviction is that it does not show up more because when this phenomenon happens, you’re in no state to go to a hospital / participate at a trial

Why not ? Is this not part of what frequently is happening with PEM Exertion above certain aerobic threshold ⇒ glycolysis outpaces aerobic metabolism ⇒ forcing pyruvate ⇒ causing lactate accumulation I presume my main energy production in my muscle cells is impeded because of an impaired oxygen...

I think the Work-Well foundation has written up some rules. But I’m afraid is: - highly individualized - task dependent - situation dependent - infection dependent - PEM dependent As also mentioned here:

I have read a lot about ME CFS patients going above anaerobic threshold to cause symptoms and PEM-crashes. I could not find a publication at the moment, but I have had different exchanges with PEM-researcher Todd Davenport on the topic. But I’m mostly going off by my own symptoms and...

Maybe I’m an anomaly, but I doubt it, as I’ve spoken to a few more patients with exact similar symptomalogy. (But not as extensive testing because that’s just very rare) These measurements were taken in an academic hospital early in the morning before even getting out of bed. Immediately...

Yes, but in my case (at least) high lactate corresponds / correlates with burning muscles. See my post below attached from a different thread. Also less symptoms correlates with lower lactate. To me this seems logical : when you are severe, you easily go above anaerobic threshold, hence...

For reference and informational purposes. 1) During a recent immune treatment of a month my lactate was measured regularly (using a catheter) in the morning waking up at rest and I stayed inpatient. So literally zero activity. Lactate (09.09.25) – 9.0 mmol/l (range 0.5 – 1.6) Lactate...

I don’t think it’s a ‘marginal difference in lactate levels’ - specifically for a subgroup. I also think it’s worthy of more research. I know that Todd Davonport has taken an interest, in this topic Maybe because I’m selfish , because it’s my worst symptom: as I type my arm Muscles are burning...

Interesting paper: - ME/CFS patients with elevated blood lactate at rest may be at higher risk for more severe PEM - Elevated (n = 55; 44.7%) and normal (n = 68; 55.3%) lactate groups were comparable except for PEM, which was more severe in the elevated lactate group I think if you can stay...

On a metabolic/mitochondrial level this might be happening: Cells shift from stuck in hypometabolic state that is ME to the hypermetabolic state w sepsis. Hypermetabolic state causes cells to actually ramp up metabolism which feels better. In sepsis there are stages which occur very similar to...

Is there a research paper you can link to? My last measured lactate level was 9 MMOL/liter (!) - measured three months ago in the morning without any exertion - the doctor considered it like early stage sepsis Again, I don’t know about this research you’re referring at. But I do remember...

First as a strong disclaimer: I have done +5 body-mind and/or BPS therapies and they harmed me more than helped me. But I’m always fascinated by patients that benefit - more than one would expect - from a certain therapy. Specially, if they’re severe. As this NPT therapy is for some reason...

I have no Research to back this up. Only my personal experience. But my fringe theory is that we decondition less because we are continuously in exercise mode: our heart as well as our muscles. - Continuously close - or above the threshold of anaerobic exercise So I agree with the fact that we...

This is the extra information I can give about extreme severe patient X : Physical and cognitive PEM near 0 Blindfolded and no phone at all 24/7 bar 1/2 messages a day (which makes it difficult to ask him many questions and assess his current situation….) Unsure if it was a real remission, as...