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https://www.nature.com/articles/s41392-020-00311-7

Summary Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associated with proliferation across many organisms and conditions. To better understand that association, we examined the metabolic consequence of activating the pyruvate...

Yes Michael, it could also be that patients are just making it all up or that mysterious illness-without-disease of yours.

I read it until I couldn't stomach the constant buzzwords and pseudoprofundity and clever attempt to secretly cure conversion disorder anymore. It's not worth reading.

It's going to be very difficult to make much progress when a small exclusive group is created and ideas are proposed that lack a solid scientific basis. They'll neither have the numbers nor the scientific credibility and my thinking is that both are essential to make progress.

President: James Lutey Vice-Presiden: David Steckel (presumably related to Colleen Steckel who has occasionally posted here) Colorado, USA https://www.guidestar.org/profile/84-3568066 Edit: there is more info here with more than just names https://www.me-international.org/board-of-directors.html

https://www.me-international.org/ Based on the content of the document, my guess is that it's a new organization by the people who made https://www.meadvocacy.org/

A news agency says that an Italian variant of the virus has been discovered in Lombardy and that it has been circulating since August. It's similar to the English variant but has an additional mutation...

The authors are clearly aware of the delayed nature of PEM so it appears unlikely that the high PEM prevalence could be mainly due to conflation of a more ordinary feeling of tiredness after exertion.

Maybe behavioural symptoms means symptoms that occur in relation to activities, like "Mentally tired after the slightest effort" or "Physically drained or sick after mild activity".

Yes, calling these behavioural symptoms just invites confusion.

Notice anything that stands out? I notice that some of these, mainly PEM, brain fog, memory issues and sensorymotor symptoms follow a similar curve. That seems to suggest they are closely related. PEM and fatigue also stand out for being so prominent. You can also see that cardiac/lung...

So long covid is mostly ME/CFS, at least in this sampled population. I wouldn't have expected such a high percentage of PEM.

By claiming that CFS is or should be classified under R.53, he is saying that patients not meeting his narrow definition of ME are merely suffering from tiredness. This kind of denialism is shocking when it comes from other patients.

I suspect there may be an association between dislike of anything to do with "CFS" and whether the patient lives in a country where the CFS label was historically used to mistreat patients in some way. Or some other cultural reason, anyway. In Italy where I live I have not seen any of this...

That makes no sense whatsoever. Whether a diagnosis is a misdiagnosis or not does not depend on whether the diagnostic criteria were created with research in mind or not. Anyway, the Canadian Consensus Criteria considers ME and CFS as "probably the same illness", uses the term ME/CFS for this...

I think you probably understand that the term misdiagnosis refers to knowing that a diagnosis was wrong (and not the property of being an exclusionary diagnosis or merely a descriptive diagnosis, of which there are many in medicine). You probably also know that there is no data you could cite to...

@Guido den Broeder this idea that CFS is always a misdiagnosis, on what is it based on?

I have this funny thought that some patients want to legitimitize their illness by constructing a founding myth of ME. This is done in response to lack of recognition and psychologization. The attempts to tell a story that doesn't quite fit reality can make it look like disbelief and...

This statements seems entirely baseless to me, one of these false ideas that circulate because they aren't being challenged properly in certain circles. Presumably by CFS you mean either the Fukuda definition or what is generally known as ME/CFS nowadays (the entity described in the IOM...