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My interpretation is: in a previous study, their main finding was a mitochondrial complex V inefficiency, in cells that had been immortalized. Immortalization of cells is an invasive technique and they need to be sure that this complex V inefficiency is due to ME/CFS and not the immortalization...

I can see how it could easily happen in various ways, but it's a bit complicated to explain and some speculation is involved. It has a lot to do with systematic bias and nonuniformity of the illness. The idea is that covid-19 is expressed differently in every person, depending on factors such...

RT-PCR tests have varying reliability. For example their sensitivity depends on time passed since infection onset. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240870/ It's also possible that the tests are especially unreliable for long covid patients because their expression of the illness...

The long covid groups seem to believe that long covid is often associated with mild initial disease and not having antibodies on tests. Yesterday I read that antibody tests have low sensitivity in women. That could lead to an underestimation of long covid as the people with negative tests are...

The glutamine caught my attention because my mother says she needs to take glutamine before going to sleep or she will wake up from hypoglycemia or epilepsy (the two are connected). She has suffered from mystery illness for many years and also had postinfectious ME/CFS for a while and I suspect...

Would increased expression of proteins related to the actin cytoskeleton result in increased cell stiffness?

One for @Jonathan Edwards perhaps, because some strange cell signalling appears to be causing blood flow problems in the brain of covid-19 patients. https://jamanetwork.com/journals/jamaneurology/fullarticle/2776455

Why is this coming out now?

In Italy and many other countries society doesn't appear to have this derisive contempt towards ME/CFS that's seen in English speaking countries. Instead the main problem appears to be a lack of recognition and indifference. In the UK people in a way the topic gets more attention, more research...

I may have said it already but in Italy the term ME is generally not used. CFS still seen as a syndrome of fatigue (instead of a syndrome of exertion intolerance). Fatigue however appears to be more socially acceptable than in other countries. The desire to avoid having the illness associated...

If fatigue and muscle weakness are clearly distinct, why did Ramsay say that the way to differentiate between ME and other postviral fatiguing illness was illness duration and symptom variability throughout the day, rather than one group having muscle weakness and the other having fatigue?

PEM as per Ramsay could be summarized as muscle fatigueability weakness, where PEM as per the ME/CFS concept could be summarized fatigue, sickness and symptom amplification. Is muscle weakness always clearly distinct from fatigue? When I have what I consider severe fatigue I'm unable to exert...

If after the collapse of the CBT/GET approach we see an increase in biomedical research as well as more competent care, I would interpret this as evidence that the collection of ideas associated with CBT/GET prevented progress. I expect to see an increase in research and better care. One way it...

As child, I was vaguely aware that chronic illness existed. In other people, distantly, for example in people over the age of 60, who had to take pills for their heart. But not in the close family. So when my mother was chronically ill, I didn't view it as chronic illness but as some weird...

We're being asked to believe in magic, or that is how it comes across. How would this wonderful self-suggestion work? Also, if patients don't have a real disease because there is insufficient objective evidence, why are we being asked to believe in other things without any evidence, like this...

They are so out of touch with reality it's astonishing. And these privileged professors have such a need to be victims when in a debate with sick patients.

NaV = voltage-gated sodium channels. From https://www.nature.com/articles/srep42810 You're right.

I didn't think of it that way. I thought the "recovery process" was a slow return to normal from what is a state of altered physiology meant to maximize survival chances in infection or injury. In the early years of the illness I've often felt like I was recovering, but then at some point along...

If PVFS and ME/CFS are the same thing, except that ME/CFS lasts much longer and is commonly lifelong, then perhaps the difference is just some factor that prevents the recovery process from completing.