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Half-life of Dara is around 3 weeks. You think it might actually be a lot longer (e.g. plasma half life vs. biological half life)? By the NK cell dynamics, do you mean the interesting thing is the difference among patients (responders vs. non) or the general pattern of depletion/repletion or...

It’s a university press release.

I’m not sure if this is the main thread for DSQ, but I'm not in love with Q 11 (cold limbs), Q12 (feeling hot or cold for no reason) Q 14 (some smells make you feel sick. Are these ME/CFS symptoms?

According to Habets: According to dr Habets, low dose Tecli is needed because of high number of gpcr antibodies so CSR {{cytokine release syndrome I think}} is much stronger than in myeloma patients. Does this make any sense @Jonathan Edwards Thanks.

Sometimes I think “low dose” approaches might be justified, especially if there is suspicion that “big pharma” might be trying to maximize dosages for profit. But I have no idea here.

Does anyone have access to this full article? https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01338-6/abstract Does the data in here support “low dose” tecli? @jnmaciuch ? Thanks

One suggestion—might be useful for @dave30th to try to interview Derya to see if he (Derya) can specifically drill down on AI and ME/CFS—instead of posting dog drawings and Einstein videos.

Prompted to make this poll in light of Derya Unutmaz’ X account which is a non-stop orgy of fawning posts about how great all AI programs are.

Also discussed in this thread. https://www.s4me.info/threads/can-large-language-models-llms-like-chatgpt-be-used-to-produce-useful-information.45540/

Will AI programs/models significantly aid in producing viable treatments for ME/CFS?

“Therefore, the upregulated [¹¹C]K-2 SUVRWM in patients with Cog-LC may indicate increased surface-expressed AMPAR density. Therefore, non-competitive antagonists of AMPAR, such as perampanel, may be a therapeutic candidate for Cog-LC. This should be tested in future randomized controlled...

https://pmc.ncbi.nlm.nih.gov/articles/PMC5083075/

https://www.s4me.info/threads/fycompa-for-brain-fog.41451/ https://www.s4me.info/threads/der-spiegel%E2%80%94sucessful-ish-treatment-of-a-german-mecfs-patient.31805/

Were there dose response studies done on Tecli? Maybe this: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)01338-6/abstract

https://neurosciencenews.com/als-autoimmune-disease-29757/

Last one—-I promise I won’t post anymore on this thread. Here is arcade-style immunotherapy.

That’s all good. But I thought he was/is funded by US taxpayers to do ME/CFS research and not spend hours posting AI slop.

Long COVID associated with SARS-CoV-2 reinfection among children and adolescents in the omicron era (RECOVER-EHR): a retrospective cohort study Summary Background Post-acute sequelae of SARS-CoV-2 infection (PASC) remain a major public health challenge. Although previous studies have focused on...

Except that this is supposedly close to what Newton sounded like…I guess AI missed this.