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2022, and it's still only "promising".

And to distrust their own feelings and perception of symptoms - also not good.

Conflicts of interest? Yep Declared conflicts of interest: Undeclared conflicts of interest: Sagol Center for Hyperbaric Medicine and Research employees Shani Zilberman-Itskovich Merav Cataglona Efrat Sasson Karin Elman-Shina Amir Hadanny Erez Lang Shachar Finci Nir Polack Gregory Fishlev...

Because the quality of the research, and the likelihood of it influencing the understanding of ME/CFS for the better matters deeply to us. Whereas for Reviewer #2, and Reviewer #1, it's often just a matter of getting the peer review done quickly, so they can cross it off the list of jobs to do...

There are no new studies here, it's a review of previous work, mostly by these authors. We'd have to look at the references to see how strong the results are. The conclusion suggests the authors are looking to trial these treatments in people with ME/CFS.

ME Genetics Research Symposium, Edinburgh, 14th September 2022

Thanks AP, interesting. It assumes 26 million of the 87 million confirmed surviving Covid-19 cases have PASC - roughly 30%. It doesn't seem to have any sort of recovery function for PASC numbers, it's just a cumulative figure. It's surely a major over-estimation. The AAPMR surely have a...

I didn't actually mean it as 'mild' plus 'moderate', I meant it as at the worse end of mild, the better end of moderate. Although of course ME/CFS levels are vague and variable.

Did anyone else enjoy the name of the man who founded the Cyprus Long Covid centre offering aphaeresis for micro clots? (screenshot)

I thought Dr Galante's quote was worth posting in full, from the SMC material linked by MSEspe. I liked the recognition of the importance of follow-up outcomes. Professor Dame Wykes, (she of the ' easy solution' comment) said: Techniques beneficial personally for the teachers - well I guess...

Very sorry to hear that you have been unwell @DMissa. I hope you are feeling much better. Thank you for being here and your very helpful attitude to patient engagement. It lifts my sprints to see a researcher thinking in this way. I haven't read this paper yet, but I wanted to make what...

it goes without saying here, but perhaps the author needs it spelled out - maybe they will find this thread one day n=1 (how many other patients was this treatment applied to who gave up and went away, or stuck with it, but didn't improve before the researchers found this one 36 year-old man?)...

Thanks Tom. I think Covid has fundamentally changed universities, with most teaching offered online as well as, or instead of, in person. So, that creates opportunities for the person with ME/CFS to record lectures, and/or do teaching online in real time. Another advantage of academic work is...

Some art/craftwork producing high value items might be suitable for some people e.g. furniture making; knife making; quilting; jewellery. The sort of thing that can be done in fairly short bursts, and stopped if symptoms start. Maybe writing? I think if you get ME/CFS after you are...

Fantastic twitter thread by E Krebs, thanks Andy

I'm assuming this idea that signals from the innate immune system produce CAD which produces the itaconate shunt, causing reduced energy production is solid. My impression was that that is established biology, and it makes sense as a short term strategy. So, I think it's a reasonable place to...

Oh, that's disappointing. But thanks to the researchers for their careful work following up a lead. No pressure, DecodeME! :)

As an example of experiments being done, it was mentioned that Chris Armstrong and his team are working on measuring itaconate using MMR, using C13 tracer to see whether cis-aconitate is being turned into itaconate. He's also working on the idea that there is a build-up of ammonia resulting...

If the hypothesis holds, then it's still likely that some glucose and fats are getting processed in affected cells. And it is proposed that only some cells are affected, with perhaps people with more severe disease having more cells with the itaconate shunt operating. So, I don't think anyone...