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Sure. Rob was careful to say this is an hypothesis, - that it sets up questions to be tested with real data. They have a mathematical model of the various processes and are inputting actual data on fluxes to try to understand how it all works. He wasn't saying that people with ME/CFS have a...

Just on the genetic possibilities, Rob did mention that there were gene mutations that might predispose someone to problems with the itaconate shunt. He mentioned for example that there are common mutations in CLYBL, an enzyme that acts on citramalyl-CoA, that reduce its effectiveness.

Here's a screenshot of one key idea. See the red "Innate immune trigger" in the top right? It should only function for a few hours or days, while the adaptive immune system with its t-cells and b-cells and antibodies gears up. It tells the cell to go into low energy production mode, so that...

Rob is a very nice man and I'm really pleased that he's working on this. Good to hear about the collaboration with Chris Armstrong's lab and Ron's lab, and great to hear that Vinod Khosla is funding work on this in Rob and Chris' labs I have 5 pages of notes from the video. It is a good...

For a study seeking to do this, the abstract is very unrevealing. Of course there were more females, because everyone knows that females are more likely to have FND... A quick google tells me that 40% white and 33% Hispanic is an unremarkable racial mix for the places the study was done in...

Nice idea, but doesn't it seem a bit far fetched when it comes to the actual data? The Neolithic period is the first agricultural revolution - when farming was first adopted. That's a long time ago - 4500-1700 BC in France according to Wikipedia. They claim that data in the 1870s shows that...

It was going pretty well until the treatment section. How he reconciles this sort of cure and improvement rate (which look very very much like the natural incidence and effect of ME/CFS): with the special multidisciplinary treatments that only Prof Milovanovic offers, I don't know. But two...

A disappointing abstract from Fred Friedberg, President of IACFSME: Non-improvement in chronic fatigue syndrome: relation to activity patterns, uplifts and hassles, and autonomic dysfunction, 2022, Friedberg et al

Have a look at the twitter thread. After a long list of congratulatory tweets, there are some critical ones.

Just so we know who we are dealing with, here's Daniel Quintana's biography - he's the senior author on this:

(I wrote this when the paper was briefly double posted, and so I didn't have the benefit of all of the foregoing comments.) Friedberg, Fred; Adamowicz, Jenna L.; Bruckenthal, Patricia; Milazzo, Maria; Ramjan, Sameera; Quintana, Daniel Friedberg is President of IACFSME. He's been working on...

I don't think they actually do that. So, I think they are assuming that OI symptoms correlate with the degree of cerebral blood flow - and so they are equating low cerebral blood flow when upright with OI. None of the 122 ME/CFS patients included in the study had hypotension or tachycardia...

Very sad news that Retha Viviers, founder of the South African ME/CFS Foundation, a staunch advocate for people with ME/CFS and a member of this forum has died. We have an In Memory thread for her here: Retha Viviers

Yes, it's something that could legitimately be said about a treatment that hasn't been researched well yet. But to say that for something like CBT or exercise aiming to improve ME/CFS, things that have been researched again and again for years, in all sorts of permutations, is a just a triumph...

To summarise, from the abstract and the points made above: They found that people who have POTS symptoms, including potentially falling over if they don't sit down when feeling faint, think about their body sensations more than people who don't regularly have such symptoms. They found that the...

Your alexithymia* is showing @Peter Trewhitt You didn't realise how afraid of standing you were. (;)) Absolutely incredible. And so the variability from one day to the next is because some days we are easy frightened and other days we are braver?

Not claiming either of those things, but I have read it. It's tempting to go through it section by section and pick it apart, but that would take a long time and probably wouldn't achieve much that is good. I think it's a good document with some interesting ideas. It's obviously a consensus...

I do think that cadherins are worth looking at more. Toxins from some dinoflagellates disrupt cadherin function. This may be a mode of action in ciguatera fish poisoning (CFP). Some people affected by CFP go on to develop a chronic illness that is a lot like ME/CFS. (I haven't looked into...

Hmm. 'Psychological' gets thrown in there, even though no evidence for that view is specifically cited. Hmm Given what we know about the problems of some antidepressants, the suggestion that they are potential therapies is concerning. Note mention of a UK study of LDN that is currently...

Safety and efficacy of low dose naltrexone in a long covid cohort; an interventional pre-post study, 2022, O'Kelly et al A small preliminary study of LDN by a group of Irish researchers: Brendan O'Kelly ab Louise Vidal b Tina McHugh b James Woo a Gordana Avramovic b John S.Lambert ab a...