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A post about a video of an interview with Resia Pretorius and her research into microclotting has been moved to the dedicated thread here Persistent clotting protein pathology in Long COVID/PASC is accompanied by increased levels of antiplasmin, 2021, Pretorius et al

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I've received a reply to my Freedom of Information request, trying to find out who bears responsibility for the comments provided by Newcastle-upon-Tyne Hospital Trust on the NICE ME/CFS Guideline. It's not very informative, other than suggesting that the comments are not the result of a rogue...

Yes, I think that is exactly right. So the prednisone is not fixing at least some of the parameters listed as contributing to Dimension 2. Those parameters are listed below, roughly in order of contribution. Levels are relative to those for the healthy controls (bearing in mind the small...

It looks as though the prednisone did change quite a number of blood/immunology characteristics. There's the question of whether that translated into any real change in symptoms though. The results are presented in Supplementary Table 1. It's attached here - sorry about the size. Each of a...

What they didn't find: On the ongoing question about natural killer cells - for this small Long Covid sample, no differences: On autoantibodies - nothing consistent in what they tested:

The study used flow cytometry to find the different cell types. It would be good to know more about how to judge if that has been done well or not. This paper (which is interesting besides its comment on flow cytometry) Non-Classical monocytes display inflammatory features: Validation in...

See the CD11c DC in Figure d above? It's the first row of the red and blue analysis. The patients before treatment clearly had higher levels of CD11c (lots of red), and lower levels after treatment. They looked a lot like the healthy controls for that parameter after treatment. Edit to add -...

Spanish study Very small - 5 healthy controls who had had Covid-19 Nine with Long Covid after mild infections (3 to 13 months) - they contributed a baseline blood sample. Only 8 of the 9 were treated - 4 days of prednisone (30mg/day), all providing a post-treatment sample. 4 months later...

Manuel Javier Arrayás-Grajera 1 Inmaculada Tornero-Quiñones 3,4,*, Blanca Gavilán-Carrera 5 Octavio Luque-Reca 6 Cecilia Peñacoba-Puente 6 Ángela Sierra-Robles 3,4, Ana Carbonell-Baeza 7,8 Fernando Estévez-López 9 1. Department of Human Motor Skills and Sports Performance, Faculty of Education...

Argh. One for the 'correlation does not equal causation' bucket. Seriously?

@Medfeb, I think it's important to be aware of this recent paper, and the many problems with it. Julia Newton (also part of the Cochrane exercise therapy review) was a co-author of this study, and may believe its conclusion that "[Individualised Activity Program] reduces fatigue and improves...

I agree things are unclear, and yes, I think the separation of the CRESTA clinic and the ME/CFS service was not understood when recent comments on the Cochrane thread were made. It would be good to find out the facts. And yes, it would be great if someone who knows Julia Newton could ask her...

Development and User Experiences of a Biopsychosocial Interprofessional Online Course on Persistent Somatic Symptoms, 2021, Rosmalen et al Thread on a concerning BPS training course - helping doctors deal with those difficult patients.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2428896/ Abstract Many post-infectious syndromes have been recognized in the last 50 years, some following viral infections and others closely related to bacterial disease. The occurrence of prolonged fatigue following an apparent viral illness of...

Not to diminish the tragedy of anyone getting Long Covid, or wish for a variant that is more effective at causing Long Covid, but if there was one, perhaps it would provide a clue as to what particular characteristics make a pathogen able to cause a post-infective fatigue syndrome.

Looking over Newton's Feb 2021 presentation to POTSUK on fatigue management, she notes that 30% of people with a diagnosis of POTS responding to a POTSUK survey also had a diagnosis of CFS. Given that a diagnosis of POTS might preclude someone subsequently getting a CFS diagnosis, it is likely...

The certainty of the authors that patients don't have anything physically wrong, the idea that a convincingly performed physical examination will provide sufficient reassurance to the patient, the packaging up of it all as an online course so medical professionals can have their prejudices...

There was a recent study, I think an Italian one of Long Covid that reported the results of a survey measuring general health by each question. It added a lot of richness to the results, highlighting which specific areas differed from controls. As well as the Likert scale issue being...

Oh, they have a very strong concept of the worst patients, that's the problem. :) It's those damn people with 'severe ME/CFS' who just stay sick to spite the clinicians; they don't want to get better.