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So, cortisol wasn't affected by the psychotherapy intervention. I note that the abstract doesn't say whether the psychotherapy intervention had any impact on the results of surveys of impairment, or on numbers of people on sick leave. (edited) I'm not sure I care enough to go see if the paper...

Here's something about Serpina 5 - I'm posting it at least partly because I like the title: Cell penetrating SERPINA5 (Protein C inhibitor, PCI): More questions than answers A 2016 paper, perhaps coincidentally by two people also based in Vienna. SERPINA5 binds glycosaminoglycans...

They make quite a lot of IL-18 levels being lower in the LCS group, but there's a lot of overlap with the other two groups- I'm not convinced there is a real difference in IL-18. But, some of the the LCS group do look different from the healthy groups - look at the PCA and volcano plot...

There are four groups: H - healthy, vaccinated at least 3 months ago, no covid 19 infection - 13 people HL - healthy, no covid 19 infection, given tablets containing 870mg Omega-3 (420 mg EPA and 330 mg DHA) twice a day for one week - 10 people R - recovered from a Covid-19 infection at least...

A team entirely from Vienna, Austria: There's acknowledgement that LC isn't just anxiety and stress. There's a good list of symptoms, although 'lack of physical fitness' would have been better replaced with 'post exertion malaise and easy fatiguability'. The severity of the disease is noted...

From that quote above: We have a thread on that later paper here: Acute Phase Phospholipids Related to the Cardiolipin of Mitochondria in the Sera of Patients With CFS, ciguatera, GWI, 2008. Hokama et al

This is an old paper, one that I remember reading early on in my illness and that I felt might be important, although I can't find a link to the full paper now. I think it's an intriguing idea, that the body is producing toxins as a result of "certain disease conditions and environmental...

Abstract The membrane immunobead assay results on the acetone lipid fraction of serum from chronic fatigue syndrome (CFS) patients (60 samples) and normal individuals (with no clinical CFS or other disease symptoms) showed significant differences with 4 exceptions (4 normals showed 1:40 and 1:80...

I really should go and do something useful. But, I thought you might enjoy this 2 minute promotional video https://www.virchicago.com/the-interventional-initiative-featuring-our-own-dr-smith-on-pelvic-pain/ I'm agnostic on the interventional radiology treatment of pelvic congestion - it looks...

Just adding - MEPedia on Peter C. Rowe. Looks a though he has been interested in pelvic congestion syndrome for a while.

The full list of authors probably sheds some light on that: Steven J Smith1, Michael Sichlau1, Luke E Sewall1, B Holly Smith2, Brenda Chen3, Neal Khurana4, Peter C Rowe5 Peter Rowe, seems to be the one we know - he's keen on the hypermobility - ME/CFS link and neck surgery too I think. The...

That they need to start learning how to be qigong masters, because the practice produces outcomes that are as good as CBT and it sounds more fun, with its pressure sensing glove and all?

Here's an explanation of how TFEB becomes activated (TFEBa) so it can then potentially go on to turn on the itaconate shunt): (Basically, the TFEB molecule sits in the cytosol, inactive. Then, when there is some adverse condition e.g. starvation , infection, ROS, ER stress or mitochondrial...

Itaconate produced by mitochondria can be moved into vacuoles containing pathogen bacteria where it inhibits pathogen proliferation. Most of the authors of this article are based in Freiburg, Germany. I thought the mention of iNOS as an inhibitor of itaconate synthesis was interesting...

Interesting paper, confirming the itaconate shunt as a means of controlling bacteria in macrophages and demonstrating that measuring levels of itaconate in cells is straight-forward.

This survey tells us nothing. With a response rate of 7%, the self-selection bias will be through the roof. Add to that two other problems with the sample: the high likelihood of mis-diagnosis of the PCS condition, either by doctors or by self-diagnosis, and of the various co-morbidities...

I actually thought that response by Walensky was ok. 'Manifestation' might not be the best word, although it is reasonably accurate, but it is true that there are a range of health impacts following Covid-19. I think it is useful to be very clear that 'Long Covid' covers a range of symptoms...

agreed Yes, I edited my post about the 'health problems' reporting. I see that there were a lot of detailed questions about sick leave in the survey. It would have been good to see some of the results from those in the paper. 'Full-time sick leave' seems to refer to taking a whole day/week...

[See my post below - I have understood full time and part time sick leave differently from what was intended - full time sick leave is taking a whole day off, not being on sick leave all of the time since the Covid-19 test.] I think monitoring of sick leave is a good thing for studies to do, as...

I interpreted 'self-reported health problems with new onset between the test date and until 6-12 months after' as a new health problem starting after the Covid-19 test date (and probably having an ongoing impact), rather than as symptoms of the acute infection and a few weeks after. But I see...