Search results

I am kind of surprised that the long covid cohort was not screened for fibromyalgia. But I guess they had no other opportunity.

Very late, but: https://pmc.ncbi.nlm.nih.gov/articles/PMC10759977/ https://cellergypharma.com/

How dangerous is this? Is this erasing all LLPC immune history? E.g. all vaccination LLPCs gone?

Going by US numbers shouldn't it be quite equal (didn't find the specific literature for CCC/ICC)? https://me-pedia.org/wiki/Prevalence_of_myalgic_encephalomyelitis_and_chronic_fatigue_syndrome https://www.dysautonomiainternational.org/page.php?ID=30 For the second point (and the rest), I...

Isn't that why it's commonly reffered to as a syndrome? Same diagnostic criteria fulfilled, possibly many different root causes. Like ME/CFS. And can't you have a downstream effect that is quite indicative of a disease without being significantly tied to the symptoms? Me being upright doesn't...

The lady (who did it for a long time) didn't tell me. Just that I should be in between firmly standing and not. Though I also think you can't completely control it. But it was clear she was not that well versed with POTS, thought it was always symptom free lying down. And suspected POTS is...

From my experience with a tilt table test, the details of the execution are very important. This concerns the way the feet are reaching the bottom "panel" of the table. If your feet are levitating (shouldn't be I think), if they are firmly on the panel or in between. Depending on the "pressure"...

Thank you! Well, I've kind of given up to find this within a "normal" known disease, my (helpful) neuro also has no idea. Thanks for the recommendation with the symptom checker. Just over time it got more and more obvious that it's not only a neuro feeling but really something that has a...

Hi, one of my symptoms is 24/7, 360° tension, pressure and burning pain in whole arms & from leg ankles till upper stomach & within the head. I also have POTS and it feels like my body's own compression garments. All this started shortly after a covid vaccine, head first and shortly after...

Cells are not destroyed but activated / blocked by "functional" autoantibodies, cf. the first article of my last post. Google Translate doesn't let me copy the relevant part of the article, it's in the beginning. But there are many other papers detailing this online.

Certainly. Based on your posts I know that you're critical to that theory, but at least for me it's the one (an unusual type of functional "autoimmunity") with the most evidence behind (not only talking about ME/CFS papers but based on the whole picture with related diseases e.g. like Post...

I'd be careful with machine translating from Japanese, even if it reads quite well. A native or near-native speaker might shed more light on this. The concept of the language is very different to English and often 1:1 translation is not possible and doesn't capture the full meaning of the native...

Well for CD19 (as you know) it at least targets additional stages of B cells. I thought I remembered Scheibenbogen talking about more efficient CD20 drugs, but I may be wrong. Other than that, nobody ever tried IgG reducers like Efgartigimod, another avenue. Regarding Rituximab, I found this...

I guess cost plays a role if there's no support by a manufacturer. But yes, a more efficient CD20 drug or also CD19 like Scheibenbogen is aiming for would be more sensible I guess.

In that case it should be even more weird that the negative SD of LC-POTS significantly goes into the non-POTS regime (<30bpm), right? And that's only 1 sigma. For me it was actually quite simple at TTT: it nearly instantly went to a value of >40bpm at tilt and was stable at +-2 bpm over 10...

1. If 38% of your HC have "reduced" IENFD on skin biopsy, doesn't this make the definition quite useless? n=10 but still... Does anyone know how it is in the Fibromyalgia studies with roughly 50% positive in meta reviews? Unfortunately, I can't find a positive rate for HC there. 2. +31.1±20.3...

It really is a rabbit hole. The best way if one wants a deep understanding is imo literally to "do the math" from the beginning and forget the intuition. Write it down mathematically & deduce what is desired via known theorems (shortly spoken). Unfortunately I can't do that kind of deep...

"having a high p-value is indeed evidence in favor of the null hypothesis, because a high p-value is more likely to occur if the null hypothesis is true than if it is false." I have a problem with that statement (if the "evidence" is supposed to be meaningful evidence). This is from a well...

Agree. To be honest, I don't know (not judging your statement in any way) if that conclusion can be drawn directly from from this test. Usually the null hypothesis being true isn't talked about in frequentist statistics since that's a bayesian idea and things get "funky". This covers the same...

Thank you! Well in that case, the p-value reported should be 1-p. Can't really say more based on the abstract. Maybe - hate to say it - this ties into the "casual" usage of statistics which is common in medical papers. Arguably the general topic is very complicated if one digs deeper and wants...