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From @Snow Leopard's post and link, it is saying that anything less than 70% efficacy cannot achieve herd immunity. Presumably this efficacy herd immunity threshold will differ depending on disease and its growth rate? If so, does that mean that the new variant of Covid 19, with its...

This NHS web page says 21 days interval between doses for Pfizer, though very woolly about implications of longer interval.

So is this Oxford vaccine identical to that originally trialled? And the most recently published results for both dosing regimes unchanged? And do they still have no idea why the difference? Also, given they are saying the more effective regime is half a shot first, then a full shot 2 or 3...

I would just amend slightly to "make stuff up and hope people don't care, or if they do care then hope they can't do anything about it ... in which case why should we care?"

Let's hope their evidence for efficacy and safety will not be reliant solely on serendipity.

Agree with you, but I very much believe we do do better here, because we are invariable dissecting this sort of stuff. This thread is not a bad example: https://www.s4me.info/threads/greetings-from-rotterdam.18299/ Whiffly stuff might get mooted, and in a science-based forum that is important...

I don't see any mention of CBT in the article. It seems to simply be saying there will be many people who will suffer mental health consequences and that many of those will need help. I'm not going to criticise an article for some indiscretion that it has no evidence of it exhibiting. I've...

[my bold] Absolutely. The terminologies and their ambiguities are a maelstrom of contradictions and confusion; the very last thing one would hope any scientist considers to be evidential.

Well said.

Which is why "behavioral symptoms" is such a confusing and potentially misleading terminology.

When I google "dsq questionnaire" or "dsq-2 questionnaire" I see nothing re the questionnaire that shows anything of "behavio" in them at all. Though mentioned and referenced in places that include behaviour/etc on their site or in their name. Only done a brief look.

I agree to a degree. There will be some people and families who will suffer the mental consequences for a long time down the road. Loved ones lost, not able to say goodbye to them. Long striven-for livelihoods destroyed. Etc. One of my grandfathers was pretty comfortably off, albeit by no means...

I don't understand that.

Yes, I had glandular fever in my late teens and it takes a while to get over it. I also strongly suspect I had a few relapses over a good many years after.

Brilliant. Well done.

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Looking back at the 2016 link, there is a comment by "Ian" on 30 Sep 2016 that I'd better not repeat here. But amongst all the other excellent comments, this one really tickles me as a very eloquent piece of Anglo-Saxon, that in a way says it all :). And of course, very well done to Jerome...

Thanks :). Yes, I was trying to pin things down a bit by saying "due to the intervention alone", but I appreciate that still does not cover the point you make. How about: For a clinical trial to be described as "controlled", there must be adequate suitable controls in place to allow any...

Thanks Jonathan, that is very helpful. Yesterday evening, given yours and others comments here, I thought it might be helpful to come up with a short definition of what the "controlled" aspect of a RCT actually means. Then checked myself with the thought that I would be reinventing a wheel much...