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@Jonathan Edwards (and others): two things I still want to get a better grasp on from your hypothesis. If you would humor me (again maybe it's a bit too specific, let me know). Disease severity and worsening: Would the baseline severity of an individual be a function of the sensitivity of...

Still, won't pushing through lead to more "false" signalling? And even if these signals are "false", aren't they still the cause of symptoms and limit our abilities? How could pushing through lead to any improvements in that case?

This is also very true for me.

Interesting, that seems to makes sense! I will say that the more I overdo it, especially physically (i.e. "exercise") the more likely it is PEM does follow swiftly in spite of lots of stress (tired but wired feeling). Anyways, I have not much more to offer than my personal experiences. The...

That's fair. Maybe it's too specific. I'm mostly wondering if the hypothesis is congruent with these observations. Like, if PEM is caused by the immune system putting the brakes on our body, does it make sense that stress hormones can delay this process or even (temporarily) mask/override it.

Hi all! First comment on this forum.. :) Wanted to say thanks @Jonathan Edwards. I appreciate the work you and many others do to try to solve this disease. Fills me with gratitude and hope. Earlier in this thread @JemPD asked the following: I experience something similar and I'm also curious...