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There isn't reasonable evidence that there are any "asymptomatic" cases at all. I suggest such assumptions based on poor test specificity. There can be pre-symptomatic cases if tested right before the patient realises they are developing symptoms. Similarly, survey questions can be limited (eg...

Brain scanning, 19th century style! https://www.npr.org/2014/08/17/340906546/the-machine-that-tried-to-scan-the-brain-in-1882 Also notably, Angelo Mosso wrote a textbook on fatigue (La fatica) in 1891, the ideas of which have been repeatedly (re)"discovered" over the decades since.

Exactly. If cognitive and/or behavioural therapies actually led to remission, we'd all be in remission by now! It boggles the mind that anyone could think that LP could be any more effective than generalised CBT. Stoic, is that a nice way of saying laid-back and lazy? :p

Nothing new here. Lloyd claiming that CFS/ME can be a positive dianosis and extensive testing should be ruled out. He states the fatigue is not genuine weakness. He says that besides the fever, the symptoms of CFS are like that of an infection that never resolves and that occurring after an...

I must admit I first thought theDurdle Door cliff thing was a joke about people being lemmings...

Indeed. Seems strange that we can't find any more info about what they are actually doing.

Wow, how did all the crap about "moderate" make it through to the final publication, given all that discussion?

None of those conclusions are justified given the tiny sample size and no control group. The claims of CRHR2 upregulation do not seem to be associated with any (hitherto) published data. The higher dosage may have resulted in slightly lower symptom scores in 2(!) participants, but one of those...

Which begs the question how?

I've long been suggesting that ACE2 dysregulation is the key problem, but I doubt very much that it is genetics that will explain the variance.

Do you think living in a tribal scenario, living without permanent shelter, relying on insecure food sources and potentially under threat from warfare is any less stressful? What is a "normal" level of cortisol or adrenaline?

They think PEM is Boom-bust! ;) Also note the boom-bust categorisation was post-hoc.

It's Alexandra Elbakyan and you can block components of a website with ublock origin (Chrome based browsers) or similar in other browsers.

I doubt it. There is also another study claiming that coronavirus immunity is not maintained. https://www.medrxiv.org/content/10.1101/2020.05.11.20086439v1 The serological findings suggest that where there is significant genetic variation of the antigenic proteins, immunity is not maintained...

Sigh. Wyller has repeatedly tested and failed to find an empirical foundation for his "sustained arousal" hypothesis. I suggest the same will be true for the "Lightning Process".

The problem with HRV as a measure is the underlying causes are very non-specific. Reduced fitness itself can explain the difference between patients and controls and reduced fitness is a likely consequence of greater severity of the underlying illness. Mere association is not enough to derive...

I was thinking which would I rather do, and the answer is none of them, but I guess I'd rather do the 6MWT, followed by this test, followed by the step test followed by the CPET in last place if forced to make a choice. The protocol: Also, on second reading, I note the curious omission of the...

That is not what was shown though. This is not a specific biomarker. It is difficult to control for effort (and difficult to directly examine the coupling between peripheral and central fatigue), so it is easy for researchers, including the authors of this thesis to simply conclude that the...

Hypotheses of fatigue are discussed, though managed to overlook the endothelial dysfunction hypothesis - an aspect that could be shared between CRF and CFS. The usual (questionable) demarcation between central and peripheral fatigue that ignores any couplings between metabolism and regulation of...

Yes, and I've always wondered why!